P-glycoprotein expression and multidrug resistance in adrenocortical carcinoma

Stuart D Flynn, J. R. Murren, W. M. Kirby, J. Honig, L. Kan, B. K. Kinder

Research output: Contribution to journalArticle

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Abstract

Background. The response of adrenocortieal carcinoma (ACC) to adjuvant chemotherapy has been disappointing with no significant impact on survival. The normal adrenal cortex has very high levels of P-glycoprotein, an energy-dependent efflux pump of a variety of structurally unrelated chemotherapeutic agents. P-glycoprotein has been implicated as a cause of multidrug resistance in a variety of neoplasms. The purpose of this study was to evaluate P-glycoprotein expression in ACC. Methods. Eleven patients with ACC had paraffin-em bedded tumor evaluated for P-glycoprotein expression. These were analyzed by immunohistochemistry assay with a battery of four anti-P-glycoprotein antibodies (MRK-16, JSB-1, UIC-2, MDR). Results. All eleven cases showed intense, predominantly membrane immunoreactivity for P-glycoprotein. In 10 of the cases, most tumor cells were immunoreactive with at least three antibodies, and six of 11 cases were positive for all four antibodies. In this small series no correlation existed between P-glycoprotein expression and tumor grade, stage of disease, or survival. Conclusions. All 11 cases of ACC studied showed P-glycoprotein expression, which was similar to the normal adrenal cortex. This possible mechanism of multidrug resistance may help explain the significant chemoresistance seen in ACC.

Original languageEnglish (US)
Pages (from-to)981-986
Number of pages6
JournalSurgery
Volume112
Issue number6
StatePublished - 1992
Externally publishedYes

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Adrenocortical Carcinoma
Multiple Drug Resistance
P-Glycoprotein
Carcinoma
Adrenal Cortex
Antibodies
Neoplasms
Survival
Adjuvant Chemotherapy
Paraffin
Immunohistochemistry
Membranes

ASJC Scopus subject areas

  • Surgery

Cite this

Flynn, S. D., Murren, J. R., Kirby, W. M., Honig, J., Kan, L., & Kinder, B. K. (1992). P-glycoprotein expression and multidrug resistance in adrenocortical carcinoma. Surgery, 112(6), 981-986.

P-glycoprotein expression and multidrug resistance in adrenocortical carcinoma. / Flynn, Stuart D; Murren, J. R.; Kirby, W. M.; Honig, J.; Kan, L.; Kinder, B. K.

In: Surgery, Vol. 112, No. 6, 1992, p. 981-986.

Research output: Contribution to journalArticle

Flynn, SD, Murren, JR, Kirby, WM, Honig, J, Kan, L & Kinder, BK 1992, 'P-glycoprotein expression and multidrug resistance in adrenocortical carcinoma', Surgery, vol. 112, no. 6, pp. 981-986.
Flynn SD, Murren JR, Kirby WM, Honig J, Kan L, Kinder BK. P-glycoprotein expression and multidrug resistance in adrenocortical carcinoma. Surgery. 1992;112(6):981-986.
Flynn, Stuart D ; Murren, J. R. ; Kirby, W. M. ; Honig, J. ; Kan, L. ; Kinder, B. K. / P-glycoprotein expression and multidrug resistance in adrenocortical carcinoma. In: Surgery. 1992 ; Vol. 112, No. 6. pp. 981-986.
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AU - Kinder, B. K.

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