P450-humanized and human liver chimeric mouse models for studying xenobiotic metabolism and toxicity

Karl Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis P. Pankowicz, Qing Yu Zhang, Xinxin Ding

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Preclinical evaluation of drug candidates in experimental animal models is an essential step in drug development. Humanized mouse models have emerged as a promising alternative to traditional animal models. The purpose of this mini-review is to provide a brief survey of currently available mouse models for studying human xenobiotic metabolism. Here, we describe both genetic humanization and human liver chimeric mouse models, focusing on the advantages and limitations while outlining their key features and applications. Although this field of biomedical science is relatively young, these humanized mouse models have the potential to transform preclinical drug testing and eventually lead to a more cost-effective and rapid development of new therapies.

Original languageEnglish (US)
Pages (from-to)1734-1744
Number of pages11
JournalDrug Metabolism and Disposition
Volume46
Issue number11
DOIs
StatePublished - Nov 2018

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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    Bissig, K. D., Han, W., Barzi, M., Kovalchuk, N., Ding, L., Fan, X., Pankowicz, F. P., Zhang, Q. Y., & Ding, X. (2018). P450-humanized and human liver chimeric mouse models for studying xenobiotic metabolism and toxicity. Drug Metabolism and Disposition, 46(11), 1734-1744. https://doi.org/10.1124/dmd.118.083303