Pancreatic tumor margin detection by oblique incidence diffuse reflectance spectroscopy

Alejandro Garcia-Uribe, Cheng Chung Chang, Jun Zou, Bhaskar Banerjee, John Kuczynski, Lihong V. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In surgical treatment of pancreatic cancers, the effectiveness of the procedures largely depends on the ability to completely and precisely remove the malignant tumors. We present the ex-vivo use of oblique incidence diffuse reflectance spectroscopy (OIRDS) to detect and differentiate normal from neoplastic tissue. An OIRDS probe has been constructed to provide scattering and absorption information of the pancreatic tissue. To reveal the physiological origin of the difference in these optical signatures, the optical scattering coefficients were extracted along the pancreatic duct with 1-cm spacing. Experimental results show that OIDRS was able to successfully determinate the tumor margins based on the higher optical scattering on malignant tissue.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7895
DOIs
StatePublished - 2011
EventOptical Biopsy IX - San Francisco, CA, United States
Duration: Jan 24 2011Jan 26 2011

Other

OtherOptical Biopsy IX
CountryUnited States
CitySan Francisco, CA
Period1/24/111/26/11

Fingerprint

Tumors
margins
Spectrum Analysis
tumors
incidence
Spectroscopy
Scattering
Tissue
reflectance
Incidence
spectroscopy
Neoplasms
Pancreatic Ducts
scattering coefficients
Pancreatic Neoplasms
scattering
ducts
Ducts
cancer
spacing

Keywords

  • cancer
  • diffuse reflectance
  • scattering
  • spectroscopy

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Garcia-Uribe, A., Chang, C. C., Zou, J., Banerjee, B., Kuczynski, J., & Wang, L. V. (2011). Pancreatic tumor margin detection by oblique incidence diffuse reflectance spectroscopy. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7895). [78950J] https://doi.org/10.1117/12.875919

Pancreatic tumor margin detection by oblique incidence diffuse reflectance spectroscopy. / Garcia-Uribe, Alejandro; Chang, Cheng Chung; Zou, Jun; Banerjee, Bhaskar; Kuczynski, John; Wang, Lihong V.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7895 2011. 78950J.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Garcia-Uribe, A, Chang, CC, Zou, J, Banerjee, B, Kuczynski, J & Wang, LV 2011, Pancreatic tumor margin detection by oblique incidence diffuse reflectance spectroscopy. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7895, 78950J, Optical Biopsy IX, San Francisco, CA, United States, 1/24/11. https://doi.org/10.1117/12.875919
Garcia-Uribe A, Chang CC, Zou J, Banerjee B, Kuczynski J, Wang LV. Pancreatic tumor margin detection by oblique incidence diffuse reflectance spectroscopy. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7895. 2011. 78950J https://doi.org/10.1117/12.875919
Garcia-Uribe, Alejandro ; Chang, Cheng Chung ; Zou, Jun ; Banerjee, Bhaskar ; Kuczynski, John ; Wang, Lihong V. / Pancreatic tumor margin detection by oblique incidence diffuse reflectance spectroscopy. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7895 2011.
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