TY - JOUR
T1 - Paracoccidioidomycosis (South American blastomycosis)
T2 - Treatment with miconazole
AU - Stevens, D. A.
AU - Restrepo-M, A.
AU - Cortés, A.
AU - Betancourt, J.
AU - Galgiani, J. N.
AU - Gómez, I.
PY - 1978/1/1
Y1 - 1978/1/1
N2 - Six patients with multisystem paracoccidioidomycosis proven by serology and culture or smear were treated with relatively brief courses of intravenous miconazole. Two had relapsed following prior therapy; 6 had active pulmonary, 4 laryngeal, 2 oropharyngeal, 2 lymphoid, and 1 abdominal disease. Paracoccidioides brasiliensis was highly susceptible to miconazole in vitro; minimal inhibitory concentration was ≤ 0.001 μg/ml. Clinical examination showed a prompt and objective response in all patients, confirmed by smear or culture and X-rays; in 4/6 serological response was shown. Side effect were minor. Two patients relapsed 3-5 mo after therapy; another had a rise in antibody 6 mo after therapy and was given maintenance oral sulfa. One remains in remssion 7 mo after treatment; two given oral sulfa after response to miconazole remain in remission 4-6 mo after treatment. Paracoccidioidomycosis responds well to miconazole, but longer courses may be needed to prevent relapse.
AB - Six patients with multisystem paracoccidioidomycosis proven by serology and culture or smear were treated with relatively brief courses of intravenous miconazole. Two had relapsed following prior therapy; 6 had active pulmonary, 4 laryngeal, 2 oropharyngeal, 2 lymphoid, and 1 abdominal disease. Paracoccidioides brasiliensis was highly susceptible to miconazole in vitro; minimal inhibitory concentration was ≤ 0.001 μg/ml. Clinical examination showed a prompt and objective response in all patients, confirmed by smear or culture and X-rays; in 4/6 serological response was shown. Side effect were minor. Two patients relapsed 3-5 mo after therapy; another had a rise in antibody 6 mo after therapy and was given maintenance oral sulfa. One remains in remssion 7 mo after treatment; two given oral sulfa after response to miconazole remain in remission 4-6 mo after treatment. Paracoccidioidomycosis responds well to miconazole, but longer courses may be needed to prevent relapse.
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U2 - 10.4269/ajtmh.1978.27.801
DO - 10.4269/ajtmh.1978.27.801
M3 - Article
C2 - 686247
AN - SCOPUS:0018190296
VL - 27
SP - 801
EP - 807
JO - Nuclear Physics A
JF - Nuclear Physics A
SN - 0375-9474
IS - 4
ER -