Paralysis and early death in cysteine string protein mutants of Drosophila

Konrad E Zinsmaier, Kai K. Eberle, Erich Buchner, Niklaus Walter, Seymour Benzer

Research output: Contribution to journalArticle

300 Citations (Scopus)

Abstract

Multimeric complexes of synaptic vesicle and terminal membrane proteins are important components of the neurotransmitter release mechanism. The csp gene of Drosophila encodes proteins homologous to synaptic vesicle proteins in Torpedo. Monoclonal antibodies demonstrate different distributions of isoforms at distinct subsets of terminals. Deletion of the csp gene in Drosophila causes a temperature-sensitive block of synaptic transmission, followed by paralysis and premature death.

Original languageEnglish (US)
Pages (from-to)977-980
Number of pages4
JournalScience
Volume263
Issue number5149
StatePublished - Feb 18 1994
Externally publishedYes

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Synaptic Vesicles
Paralysis
Drosophila Proteins
Torpedo
Premature Mortality
Gene Deletion
Presynaptic Terminals
Synaptic Transmission
Drosophila
Neurotransmitter Agents
Protein Isoforms
Membrane Proteins
Monoclonal Antibodies
Temperature
Genes
Proteins
Drosophila Csp protein

ASJC Scopus subject areas

  • General

Cite this

Zinsmaier, K. E., Eberle, K. K., Buchner, E., Walter, N., & Benzer, S. (1994). Paralysis and early death in cysteine string protein mutants of Drosophila. Science, 263(5149), 977-980.

Paralysis and early death in cysteine string protein mutants of Drosophila. / Zinsmaier, Konrad E; Eberle, Kai K.; Buchner, Erich; Walter, Niklaus; Benzer, Seymour.

In: Science, Vol. 263, No. 5149, 18.02.1994, p. 977-980.

Research output: Contribution to journalArticle

Zinsmaier, KE, Eberle, KK, Buchner, E, Walter, N & Benzer, S 1994, 'Paralysis and early death in cysteine string protein mutants of Drosophila', Science, vol. 263, no. 5149, pp. 977-980.
Zinsmaier KE, Eberle KK, Buchner E, Walter N, Benzer S. Paralysis and early death in cysteine string protein mutants of Drosophila. Science. 1994 Feb 18;263(5149):977-980.
Zinsmaier, Konrad E ; Eberle, Kai K. ; Buchner, Erich ; Walter, Niklaus ; Benzer, Seymour. / Paralysis and early death in cysteine string protein mutants of Drosophila. In: Science. 1994 ; Vol. 263, No. 5149. pp. 977-980.
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