Paralysis and early death in cysteine string protein mutants of Drosophila

Konrad E. Zinsmaier, Kai K. Eberle, Erich Buchner, Niklaus Walter, Seymour Benzer

Research output: Contribution to journalArticle

302 Scopus citations

Abstract

Multimeric complexes of synaptic vesicle and terminal membrane proteins are important components of the neurotransmitter release mechanism. The csp gene of Drosophila encodes proteins homologous to synaptic vesicle proteins in Torpedo. Monoclonal antibodies demonstrate different distributions of isoforms at distinct subsets of terminals. Deletion of the csp gene in Drosophila causes a temperature-sensitive block of synaptic transmission, followed by paralysis and premature death.

Original languageEnglish (US)
Pages (from-to)977-980
Number of pages4
JournalScience
Volume263
Issue number5149
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • General

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