Paraneoplastic coma and acquired central alveolar hypoventilation as a manifestation of brainstem encephalitis in a patient with ANNA-1 antibody and small-cell lung cancer

Kwan S. Lee, Michaela J. Higgins, Bhavesh M. Patel, Joel S. Larson, Mohamed Y. Rady

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Introduction: Paraneoplastic neurological disorders are a well recognized complication of malignancy. Methods: A case report to expand the currently described clinical manifestations of type 1 antineuronal antibody (ANNA-1)-associated paraneoplastic encephalomyelitis to include coma. Results: We present an unusual case of fluctuating coma and rapid fulminant progression to acute respiratory failure from central alveolar hypoventilation caused by ANNA-1 paraneoplastic encephalomyelitis associated with small-cell lung carcinoma. Paraneoplastic infiltration of the brainstem and cerebellum, including respiratory and arousal centers, was documented on autopsy. Conclusions: Paraneoplastic encephalomyelitis should be considered as a possible cause of coma and central alveolar hypoventilation.

Original languageEnglish (US)
Pages (from-to)137-139
Number of pages3
JournalNeurocritical Care
Volume4
Issue number2
DOIs
StatePublished - 2006

Keywords

  • ANNA-1
  • Central alveolar hypoventilation
  • Coma
  • Paraneoplastic
  • anti-Hu antibody

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine

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