TY - JOUR
T1 - Paraneoplastic limbic encephalitis
T2 - Ovarian cancer presenting as an amnesic syndrome
AU - Bloch, Michael H.
AU - Hwang, Wei Chan
AU - Baehring, Joachim M.
AU - Chambers, Setsuko K.
PY - 2004/11/1
Y1 - 2004/11/1
N2 - BACKGROUND:: Paraneoplastic limbic encephalitis (PLE) is a rare neurologic manifestation of malignancy. Paraneoplastic limbic encephalitis typically presents with short-term memory loss, seizures, or other limbic system abnormalities. The majority of PLE cases are associated with lung and testicular cancer. CASE:: We present the first case of PLE attributable to an epithelial ovarian cancer. The 58-year-old woman presented with rapidly progressing short-term memory loss and amnesia. The diagnosis of ovarian cancer was suspected on the basis of computed tomography scan findings. The patient showed dramatic clinical improvement within 2 weeks of debulking surgery and after the initiation of plasmapheresis and chemotherapy. CONCLUSION:: Paraneoplastic limbic encephalitis is a rare complication of ovarian tumors that is potentially reversible with prompt surgical management of the primary tumor, plasmapheresis, and chemotherapy.
AB - BACKGROUND:: Paraneoplastic limbic encephalitis (PLE) is a rare neurologic manifestation of malignancy. Paraneoplastic limbic encephalitis typically presents with short-term memory loss, seizures, or other limbic system abnormalities. The majority of PLE cases are associated with lung and testicular cancer. CASE:: We present the first case of PLE attributable to an epithelial ovarian cancer. The 58-year-old woman presented with rapidly progressing short-term memory loss and amnesia. The diagnosis of ovarian cancer was suspected on the basis of computed tomography scan findings. The patient showed dramatic clinical improvement within 2 weeks of debulking surgery and after the initiation of plasmapheresis and chemotherapy. CONCLUSION:: Paraneoplastic limbic encephalitis is a rare complication of ovarian tumors that is potentially reversible with prompt surgical management of the primary tumor, plasmapheresis, and chemotherapy.
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U2 - 10.1097/01.AOG.0000128110.31784.c8
DO - 10.1097/01.AOG.0000128110.31784.c8
M3 - Article
C2 - 15516442
AN - SCOPUS:16544379655
VL - 104
SP - 1174
EP - 1177
JO - Obstetrics and Gynecology
JF - Obstetrics and Gynecology
SN - 0029-7844
IS - 5 PART 2
ER -