Abstract
BACKGROUND:: Paraneoplastic limbic encephalitis (PLE) is a rare neurologic manifestation of malignancy. Paraneoplastic limbic encephalitis typically presents with short-term memory loss, seizures, or other limbic system abnormalities. The majority of PLE cases are associated with lung and testicular cancer. CASE:: We present the first case of PLE attributable to an epithelial ovarian cancer. The 58-year-old woman presented with rapidly progressing short-term memory loss and amnesia. The diagnosis of ovarian cancer was suspected on the basis of computed tomography scan findings. The patient showed dramatic clinical improvement within 2 weeks of debulking surgery and after the initiation of plasmapheresis and chemotherapy. CONCLUSION:: Paraneoplastic limbic encephalitis is a rare complication of ovarian tumors that is potentially reversible with prompt surgical management of the primary tumor, plasmapheresis, and chemotherapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1174-1177 |
| Number of pages | 4 |
| Journal | Obstetrics and Gynecology |
| Volume | 104 |
| Issue number | 5 PART 2 |
| DOIs | |
| State | Published - Nov 2004 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Paraneoplastic limbic encephalitis : Ovarian cancer presenting as an amnesic syndrome. / Bloch, Michael H.; Hwang, Wei Chan; Baehring, Joachim M.; Chambers, Setsuko K.
In: Obstetrics and Gynecology, Vol. 104, No. 5 PART 2, 11.2004, p. 1174-1177.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Paraneoplastic limbic encephalitis
T2 - Ovarian cancer presenting as an amnesic syndrome
AU - Bloch, Michael H.
AU - Hwang, Wei Chan
AU - Baehring, Joachim M.
AU - Chambers, Setsuko K
PY - 2004/11
Y1 - 2004/11
N2 - BACKGROUND:: Paraneoplastic limbic encephalitis (PLE) is a rare neurologic manifestation of malignancy. Paraneoplastic limbic encephalitis typically presents with short-term memory loss, seizures, or other limbic system abnormalities. The majority of PLE cases are associated with lung and testicular cancer. CASE:: We present the first case of PLE attributable to an epithelial ovarian cancer. The 58-year-old woman presented with rapidly progressing short-term memory loss and amnesia. The diagnosis of ovarian cancer was suspected on the basis of computed tomography scan findings. The patient showed dramatic clinical improvement within 2 weeks of debulking surgery and after the initiation of plasmapheresis and chemotherapy. CONCLUSION:: Paraneoplastic limbic encephalitis is a rare complication of ovarian tumors that is potentially reversible with prompt surgical management of the primary tumor, plasmapheresis, and chemotherapy.
AB - BACKGROUND:: Paraneoplastic limbic encephalitis (PLE) is a rare neurologic manifestation of malignancy. Paraneoplastic limbic encephalitis typically presents with short-term memory loss, seizures, or other limbic system abnormalities. The majority of PLE cases are associated with lung and testicular cancer. CASE:: We present the first case of PLE attributable to an epithelial ovarian cancer. The 58-year-old woman presented with rapidly progressing short-term memory loss and amnesia. The diagnosis of ovarian cancer was suspected on the basis of computed tomography scan findings. The patient showed dramatic clinical improvement within 2 weeks of debulking surgery and after the initiation of plasmapheresis and chemotherapy. CONCLUSION:: Paraneoplastic limbic encephalitis is a rare complication of ovarian tumors that is potentially reversible with prompt surgical management of the primary tumor, plasmapheresis, and chemotherapy.
UR - http://www.scopus.com/inward/record.url?scp=16544379655&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=16544379655&partnerID=8YFLogxK
U2 - 10.1097/01.AOG.0000128110.31784.c8
DO - 10.1097/01.AOG.0000128110.31784.c8
M3 - Article
VL - 104
SP - 1174
EP - 1177
JO - Obstetrics and Gynecology
JF - Obstetrics and Gynecology
SN - 0029-7844
IS - 5 PART 2
ER -