Paraneoplastic temporal lobe epilepsy with testicular neoplasm and atypical amnesia

Geoffrey L Ahern, M. O'Connor, J. Dalmau, A. Coleman, J. B. Posner, D. L. Schomer, A. G. Herzog, D. A. Kolb, M. M. Mesulam

Research output: Contribution to journalArticle

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Abstract

We report a patient who, at age 38, presented with temporal lobe seizures and an atypical memory disorder 3 years before the discovery of a testicular tumor. Detailed neuropsychological testing revealed a relatively isolated amnestic syndrome. The amnesia was atypical as the patient could retain information for hour-long periods, only to lose it later. Serologic studies revealed the presence of a circulating autoantibody that demonstrated an unusual affinity for the nucleolus of cerebral cortical neurons. Western blot analysis of cortical neurons revealed that this antibody reacted with proteins different from other previously identified paraneoplastic neurologic antigens (Hu, Yo, Ri). We believe this to be a case of paraneoplastic limbic encephalitis secondary to the testicular tumor. This patient presents unique characteristics with respect to the mode of presentation, features of the amnesia, and the presence of a circulating antibody with an unusual reactivity pattern.

Original languageEnglish (US)
Pages (from-to)1270-1274
Number of pages5
JournalNeurology
Volume44
Issue number7
StatePublished - Jul 1994

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Amnesia
Temporal Lobe Epilepsy
Testicular Neoplasms
ELAV Proteins
Limbic Encephalitis
Neurons
Antibodies
Memory Disorders
Temporal Lobe
Autoantibodies
Nervous System
Seizures
Western Blotting
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ahern, G. L., O'Connor, M., Dalmau, J., Coleman, A., Posner, J. B., Schomer, D. L., ... Mesulam, M. M. (1994). Paraneoplastic temporal lobe epilepsy with testicular neoplasm and atypical amnesia. Neurology, 44(7), 1270-1274.

Paraneoplastic temporal lobe epilepsy with testicular neoplasm and atypical amnesia. / Ahern, Geoffrey L; O'Connor, M.; Dalmau, J.; Coleman, A.; Posner, J. B.; Schomer, D. L.; Herzog, A. G.; Kolb, D. A.; Mesulam, M. M.

In: Neurology, Vol. 44, No. 7, 07.1994, p. 1270-1274.

Research output: Contribution to journalArticle

Ahern, GL, O'Connor, M, Dalmau, J, Coleman, A, Posner, JB, Schomer, DL, Herzog, AG, Kolb, DA & Mesulam, MM 1994, 'Paraneoplastic temporal lobe epilepsy with testicular neoplasm and atypical amnesia', Neurology, vol. 44, no. 7, pp. 1270-1274.
Ahern GL, O'Connor M, Dalmau J, Coleman A, Posner JB, Schomer DL et al. Paraneoplastic temporal lobe epilepsy with testicular neoplasm and atypical amnesia. Neurology. 1994 Jul;44(7):1270-1274.
Ahern, Geoffrey L ; O'Connor, M. ; Dalmau, J. ; Coleman, A. ; Posner, J. B. ; Schomer, D. L. ; Herzog, A. G. ; Kolb, D. A. ; Mesulam, M. M. / Paraneoplastic temporal lobe epilepsy with testicular neoplasm and atypical amnesia. In: Neurology. 1994 ; Vol. 44, No. 7. pp. 1270-1274.
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