Parasite–host cell interactions in toxoplasmosis: New avenues for intervention?

Isabelle Coppens, Keith A Joiner

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Toxoplasma gondii is a protozoan parasite that is uniquely adapted for penetrating and surviving within a wide range of host cells. This parasite invades mammalian cells by an active actin-dependent mechanism, and after entry establishes a vacuole with the assistance of products secreted by the parasite's apical organelles. Simultaneously, Toxoplasma sets about gaining access to cellular nutrients by forming pores in the vacuolar membrane. In this manner it enjoys a rich and comfortable lifestyle at the host cell's expense. Understanding the Toxoplasma–host interaction may reveal unusual mechanisms for exploiting host cell pathways and diverting host organelle functions. These novel modifications could also be potential targets for new drugs.

Original languageEnglish (US)
Pages (from-to)1-20
Number of pages20
JournalExpert Reviews in Molecular Medicine
Volume3
Issue number2
DOIs
StatePublished - Jan 15 2001
Externally publishedYes

Keywords

  • host cell manipulation
  • intracellular protozoan
  • nutrition
  • parasitophorous vacuole
  • Toxoplasma gondii

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Fingerprint Dive into the research topics of 'Parasite–host cell interactions in toxoplasmosis: New avenues for intervention?'. Together they form a unique fingerprint.

  • Cite this