Parathyroid hormone release is not associated with acute sympathetic arousal in goats

P. R. Marques, D. D. Williams, L. Shen, David G Johnson, D. J. Baylink, C. C. Gale

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Physiological activation of the sympathetic adrenomedullary (SAM) axis following both thermal and non thermal stress was assessed by changes in serum norepinephrine, glucose and/or protein as well as indices of peripheral blood flow. The occurrence of elevated serum parathyroid hormone (PTH) did not reliably reflect SAM activation as might be predicted from pharmacological studies that document a beta adrenergic receptor mechanism in the parathyroid gland that mediates catecholamine stimulated release of PTH into the circulation. The beta agonist isoproterenol at 1 μg/min for 60 min did produce a transient increase in serum PTH at 20 min. Overall, the data raise doubts about the physiological significance of the adrenergic receptor in the parathyroid gland. Significant increases in serum PTH of 67% and 109% above basal respectively were seen following ruminal loading with cold and thermoneutral water. Associated with the PTH change were increased serum phosphorus and elevated or constant serum protein and serum total calcium.

Original languageEnglish (US)
Pages (from-to)57-70
Number of pages14
JournalEndocrine Research
Volume6
Issue number1
DOIs
StatePublished - 1979
Externally publishedYes

Fingerprint

Arousal
Parathyroid Hormone
Goats
Serum
Parathyroid Glands
Hot Temperature
Receptors, Adrenergic, beta
Isoproterenol
Phosphorus
Adrenergic Receptors
Catecholamines
Blood Proteins
Norepinephrine
Pharmacology
Calcium
Glucose
Water
Proteins

ASJC Scopus subject areas

  • Endocrinology
  • Medicine(all)

Cite this

Parathyroid hormone release is not associated with acute sympathetic arousal in goats. / Marques, P. R.; Williams, D. D.; Shen, L.; Johnson, David G; Baylink, D. J.; Gale, C. C.

In: Endocrine Research, Vol. 6, No. 1, 1979, p. 57-70.

Research output: Contribution to journalArticle

Marques, P. R. ; Williams, D. D. ; Shen, L. ; Johnson, David G ; Baylink, D. J. ; Gale, C. C. / Parathyroid hormone release is not associated with acute sympathetic arousal in goats. In: Endocrine Research. 1979 ; Vol. 6, No. 1. pp. 57-70.
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AU - Gale, C. C.

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