Partial sleep deprivation by environmental noise increases food intake and body weight in obesity-resistant rats

Vijayakumar Mavanji, Jennifer A Teske, Charles J. Billington, Catherine M. Kotz

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objective Sleep restriction in humans increases risk for obesity, but previous rodent studies show weight loss following sleep deprivation, possibly due to stressful methods used to prevent sleep. Obesity-resistant (OR) rats exhibit consolidated-sleep and resistance to weight gain. It was hypothesized that sleep disruption by a less-stressful method would increase body weight, and the effect of partial sleep deprivation (PSD) on body weight in OR and Sprague-Dawley (SD) rats was examined. Design and Methods OR and SD rats (n = 12/group) were implanted with transmitters to record sleep/wake. After baseline recording, six SD and six OR rats underwent 8 h PSD during light phase for 9 days. Sleep was reduced using recordings of random noise. Sleep/wake states were scored as wakefulness (W), slow-wave-sleep (SWS), and rapid-eye-movement-sleep (REMS). Total number of transitions between stages, SWS-delta-power, food intake, and body weight were documented. Results Exposure to noise decreased SWS and REMS time, while increasing W time. Sleep-deprivation increased the number of transitions between stages and SWS-delta-power. Further, PSD during the rest phase increased recovery sleep during the active phase. The PSD SD and OR rats had greater food intake and body weight compared to controls Conclusions PSD by less-stressful means increases body weight in rats. Also, PSD during the rest phase increases active period sleep.

Original languageEnglish (US)
Pages (from-to)1396-1405
Number of pages10
JournalObesity
Volume21
Issue number7
DOIs
StatePublished - Jul 2013

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Sleep Deprivation
Noise
Sleep
Obesity
Eating
Body Weight
REM Sleep
Sprague Dawley Rats
Wakefulness
Weight Gain

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Partial sleep deprivation by environmental noise increases food intake and body weight in obesity-resistant rats. / Mavanji, Vijayakumar; Teske, Jennifer A; Billington, Charles J.; Kotz, Catherine M.

In: Obesity, Vol. 21, No. 7, 07.2013, p. 1396-1405.

Research output: Contribution to journalArticle

Mavanji, Vijayakumar ; Teske, Jennifer A ; Billington, Charles J. ; Kotz, Catherine M. / Partial sleep deprivation by environmental noise increases food intake and body weight in obesity-resistant rats. In: Obesity. 2013 ; Vol. 21, No. 7. pp. 1396-1405.
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