Partial Sleep Deprivation Reduces the Efficacy of Orexin-A to Stimulate Physical Activity and Energy Expenditure

Danielle P. DePorter, Jamie E. Coborn, Jennifer A Teske

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Sufficient sleep is required for weight maintenance. Sleep deprivation due to noise exposure stimulates weight gain by increasing hyperphagia and reducing energy expenditure (EE). Yet the mechanistic basis underlying the weight gain response is unclear. Orexin-A promotes arousal and negative energy balance, and orexin terminals project to the ventrolateral preoptic area (VLPO), which is involved in sleep-to-wake transitions. To determine whether sleep deprivation reduces orexin function in VLPO and to test the hypothesis that sleep deprivation would attenuate the orexin-A-stimulated increase in arousal, physical activity (PA), and EE. Methods: Electroencephalogram, electromyogram, distance traveled, and EE were determined in male Sprague-Dawley rats following orexin-A injections into VLPO both before and after acute (12-h) and chronic (8 h/d, 9 d) sleep deprivation by noise exposure. Results: Orexin-A in the VLPO significantly increased arousal, PA, total EE, and PA-related EE and reduced sleep and respiratory quotient before sleep deprivation. In contrast to after acute sleep deprivation in which orexin-A failed to stimulate EE during PA only, orexin-A failed to significantly increase arousal, PA, fat oxidation, total EE, and PA-related EE after chronic sleep deprivation. Conclusions: Sleep deprivation may reduce sensitivity to endogenous stimuli that enhance EE due to PA and thus stimulate weight gain.

Original languageEnglish (US)
Pages (from-to)1716-1722
Number of pages7
JournalObesity
Volume25
Issue number10
DOIs
StatePublished - Oct 1 2017

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Sleep Deprivation
Energy Metabolism
Preoptic Area
Arousal
Weight Gain
Sleep
Noise
Orexins
Hyperphagia
Electromyography
Sprague Dawley Rats
Electroencephalography
Fats
Maintenance
Weights and Measures
Injections

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Partial Sleep Deprivation Reduces the Efficacy of Orexin-A to Stimulate Physical Activity and Energy Expenditure. / DePorter, Danielle P.; Coborn, Jamie E.; Teske, Jennifer A.

In: Obesity, Vol. 25, No. 10, 01.10.2017, p. 1716-1722.

Research output: Contribution to journalArticle

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