Particle interactions in dry powder inhaler unit processes: A review

Zhen Xu, Heidi M. Mansour, Anthony J. Hickey

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Recent development and methods of designing and optimizing dry powder formulations have extended the therapeutic potential of inhaled dosage forms. Successful drug delivery as indicated by a high and reproducible fine particle fraction, required to achieve the desired therapeutic effect while minimizing potential toxicity, depends on an understanding of the physico-chemical properties of powder blends, their performance and availability of adequate tools to screen and predict their behavior. The scope of this review includes three important perspectives for inhaled drug delivery: (1) Fundamental aspects of interparticulate interactions of pharmaceutical dry powder aerosols at rest and in resuspension; (2) The influences of pharmaceutical processing including milling, mixing, filling and storage, and their influence on powder dispersion; (3) Current strategies for formulation optimization and methods for in vitro aerosolization performance prediction.

Original languageEnglish (US)
Pages (from-to)451-482
Number of pages32
JournalJournal of Adhesion Science and Technology
Volume25
Issue number4-5
DOIs
StatePublished - Jan 1 2011

Keywords

  • Dry powder inhaler
  • dry powder aerosol formulation
  • formulation optimization
  • interparticulate interaction
  • performance prediction
  • pharmaceutical processing
  • resuspension

ASJC Scopus subject areas

  • Chemistry(all)
  • Mechanics of Materials
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films
  • Materials Chemistry

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