Partitioning of lung and chest-wall mechanics before and after lung- volume-reduction surgery

A. Jubran, F. Laghi, M. Mazur, Sairam Parthasarathy, Jr Garrity E.R., P. J. Fahey, M. J. Tobin

Research output: Contribution to journalArticle

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Abstract

In the study reported here, we partitioned the mechanics of the respiratory system into lung and chest-wall components, using the rapid occlusion technique in seven patients with severe emphysema before lung- volume-reduction surgery and 3 mo later. Patients showed improvements in 6- min walk (p < 0.01) and dyspnea (p < 0.05). The resistances of the respiratory system and chest wall were not altered by surgery. Ohmic airway resistance did not change, but the component of lung resistance (ΔRL) due to viscoelastic behavior (stress relaxation) and time-constant inhomogeneities (pendelluft) decreased in six patients (p < 0.03). Dynamic elastance of the lung (E(dyn,L)) decreased after surgery (p < 0.02), whereas dynamic elastance of the chest wall did not change. The ratio of dynamic intrinsic positive end-expiratory pressure (PEEP(i)) to static PEEP(i), which also reflects viscoelastic properties and time-constant inhomogeneities, increased after surgery (p < 0.05). The decrease in dyspnea was related to the decrease in E(dyn,L) (r = 0.81, p = 0.03), and tended to be related to the decrease in ΔRL (r = 0.71, p = 0.07). In conclusion, lung-volume-reduction surgery decreased dynamic pressure dissipations caused by stress relaxation and time- constant inhomogeneities within lung tissue, and it had no effect on the static mechanical properties of the chest wall.

Original languageEnglish (US)
Pages (from-to)306-310
Number of pages5
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume158
Issue number1
StatePublished - 1998
Externally publishedYes

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Pneumonectomy
Thoracic Wall
Mechanics
Lung
Positive-Pressure Respiration
Respiratory System
Dyspnea
Airway Resistance
Emphysema
Electric Impedance
Pressure

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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Partitioning of lung and chest-wall mechanics before and after lung- volume-reduction surgery. / Jubran, A.; Laghi, F.; Mazur, M.; Parthasarathy, Sairam; Garrity E.R., Jr; Fahey, P. J.; Tobin, M. J.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 158, No. 1, 1998, p. 306-310.

Research output: Contribution to journalArticle

Jubran, A. ; Laghi, F. ; Mazur, M. ; Parthasarathy, Sairam ; Garrity E.R., Jr ; Fahey, P. J. ; Tobin, M. J. / Partitioning of lung and chest-wall mechanics before and after lung- volume-reduction surgery. In: American Journal of Respiratory and Critical Care Medicine. 1998 ; Vol. 158, No. 1. pp. 306-310.
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