Passenger mutations can accelerate tumour suppressor gene inactivation in cancer evolution

Dominik Wodarz, Alan C Newell, Natalia L. Komarova

Research output: Contribution to journalArticle

Abstract

Carcinogenesis is an evolutionary process whereby cells accumulate multiple mutations. Besides the ‘driver mutations’ that cause the disease, cells also accumulate a number of other mutations with seemingly no direct role in this evolutionary process. They are called passenger mutations. While it has been argued that passenger mutations render tumours more fragile due to reduced fitness, the role of passenger mutations remains understudied. Using evolutionary computational models, we demonstrate that in the context of tumour suppressor gene inactivation (and hence fitness valley crossing), the presence of passenger mutations can accelerate the rate of evolution by reducing overall population fitness and increasing the relative fitness of intermediate mutants in the fitness valley crossing pathway. Hence, the baseline rate of tumour suppressor gene inactivation might be faster than previously thought. Conceptually, parallels are found in the field of turbulence and pattern formation, where instabilities can be driven by perturbations that are damped (disadvantageous), but provide a richer set of pathways such that a system can achieve some desired goal more readily. This highlights, through a number of novel parallels, the relevance of physical sciences in oncology.

Original languageEnglish (US)
Article number20170967
JournalJournal of the Royal Society Interface
Volume15
Issue number143
DOIs
StatePublished - Jan 1 2018

Fingerprint

Gene Silencing
Tumor Suppressor Genes
Tumors
Genes
Mutation
Neoplasms
Oncology
Turbulence
Natural Science Disciplines
Carcinogenesis
Population

Keywords

  • Evolutionary theory
  • Fitness valley
  • Mathematical models
  • Tumour evolution

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering

Cite this

Passenger mutations can accelerate tumour suppressor gene inactivation in cancer evolution. / Wodarz, Dominik; Newell, Alan C; Komarova, Natalia L.

In: Journal of the Royal Society Interface, Vol. 15, No. 143, 20170967, 01.01.2018.

Research output: Contribution to journalArticle

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