Pathogenesis, diagnosis and management of paraneoplastic glomerulonephritis

Yeong Hau H. Lien, Li Wen Lai

Research output: Contribution to journalReview articlepeer-review

77 Scopus citations


Paraneoplastic glomerulonephritis is a rare complication of malignancy that is frequently mistaken for idiopathic glomerulonephritis. Failure to recognize paraneoplastic glomerulonephritis can subject patients to ineffective and potentially harmful therapy. The pathology of paraneoplastic glomerulonephritis varies between different types of malignancies. This Review discusses the association of glomerulonephritis with both solid tumors and hematological malignancies. The pathogenetic mechanisms of many glomerular lesions seem to relate to altered immune responses in the presence of a malignancy. Studies in the Buffalo/Mna rat model of spontaneous thymoma and nephrotic syndrome indicate that polarization of the immune response toward a T-helper-2 (TH 2) profile has an important role in the development of thymoma-associated glomerular lesions. Furthermore, overexpression of the TH 2 cytokine interleukin 13 in rats induces minimal change disease. Such findings from experimental studies might facilitate the identification of biomarkers that can distinguish paraneoplastic glomerulonephritis from idiopathic and other secondary glomerulonephritides. This Review describes potential pathogenetic mechanisms for paraneoplastic glomerulonephritides associated with different malignancies and highlights the need for a multidisciplinary approach to the management of patients with paraneoplastic glomerulonephritis.

Original languageEnglish (US)
Pages (from-to)85-95
Number of pages11
JournalNature Reviews Nephrology
Issue number2
StatePublished - Feb 2011

ASJC Scopus subject areas

  • Nephrology


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