Pathogenesis of Coccidioidomycosis

Neil M. Ampel, Susan E. Hoover

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Coccidioidomycosis is a systemic fungal infection endemic to the American Southwest, caused by Coccidioides immitis and Coccidioides posadasii. The infection has a wide variety of clinical manifestations in humans, from asymptomatic infection to severe disease. Infection occurs through inhalation of fungal spores, leading to primary pulmonary infection and occasionally to hematogenous dissemination to other sites. Both fungal and host factors contribute to pathogenesis of this infection. Cellular and innate immune responses are involved in the protective response in both humans and mice. This review summarizes recent research on microbial and host factors involved in the pathogenesis of coccidioidomycosis.

Original languageEnglish (US)
Pages (from-to)253-258
Number of pages6
JournalCurrent Fungal Infection Reports
Volume9
Issue number4
DOIs
StatePublished - Dec 1 2015
Externally publishedYes

Fingerprint

Coccidioidomycosis
Coccidioides
Infection
Asymptomatic Infections
Fungal Spores
Mycoses
Innate Immunity
Cellular Immunity
Inhalation
Lung
Research

Keywords

  • Coccidioides
  • Coccidioidomycosis
  • Coccidioidomycosis pathogenesis
  • Fungal infection
  • Fungal pathogenesis
  • Innate and adaptive immunity
  • Systemic fungal infection
  • Virulence factors

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Pathogenesis of Coccidioidomycosis. / Ampel, Neil M.; Hoover, Susan E.

In: Current Fungal Infection Reports, Vol. 9, No. 4, 01.12.2015, p. 253-258.

Research output: Contribution to journalArticle

Ampel, Neil M. ; Hoover, Susan E. / Pathogenesis of Coccidioidomycosis. In: Current Fungal Infection Reports. 2015 ; Vol. 9, No. 4. pp. 253-258.
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