Pathogenesis of Coccidioidomycosis

Neil M. Ampel, Susan E. Hoover

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Coccidioidomycosis is a systemic fungal infection endemic to the American Southwest, caused by Coccidioides immitis and Coccidioides posadasii. The infection has a wide variety of clinical manifestations in humans, from asymptomatic infection to severe disease. Infection occurs through inhalation of fungal spores, leading to primary pulmonary infection and occasionally to hematogenous dissemination to other sites. Both fungal and host factors contribute to pathogenesis of this infection. Cellular and innate immune responses are involved in the protective response in both humans and mice. This review summarizes recent research on microbial and host factors involved in the pathogenesis of coccidioidomycosis.

Original languageEnglish (US)
Pages (from-to)253-258
Number of pages6
JournalCurrent Fungal Infection Reports
Volume9
Issue number4
DOIs
StatePublished - Dec 1 2015
Externally publishedYes

Keywords

  • Coccidioides
  • Coccidioidomycosis
  • Coccidioidomycosis pathogenesis
  • Fungal infection
  • Fungal pathogenesis
  • Innate and adaptive immunity
  • Systemic fungal infection
  • Virulence factors

ASJC Scopus subject areas

  • Infectious Diseases

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