Pathology of superficial bladder cancer with emphasis on carcinoma in situ.

Ronald S Weinstein, J. S. Coon, D. Schwartz, A. W. Miller, B. U. Pauli

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The coexistence of carcinoma in situ in flat epithelium adjacent to tumors is prognostically significant and is associated with an increased incidence of tumor recurrence and invasion. Recent investigations have been aimed at finding markers that will help identify flat areas of dysplasia or low-grade papillary transitional cell carcinomas that have a high potential to evolve into invasive tumors. Both DNA and karyotype analyses, as well as cell surface markers, have been examined in some detail and could have clinical value in certain settings. The tumor DNA index as measured by flow cytometry of nuclei retrieved from deparaffined sections may be particularly useful as a predictor of tumor recurrences and, possibly, tumor invasion as well. The diagnosis of superficial disease rests on urine cytology and the histopathologic assessment of tissue biopsies; however, intra- and inter-observer reproducibility of tissue and cytologic diagnoses by pathologists is a significant problem. The application of new technologies, such as flow cytometric analysis of deparaffined nuclei, may reduce the subjectivity involved in the light microscopic assessment of pathology specimens.

Original languageEnglish (US)
Pages (from-to)2-10
Number of pages9
JournalUrology
Volume26
Issue number4 Suppl
StatePublished - Oct 1985
Externally publishedYes

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Carcinoma in Situ
Urinary Bladder Neoplasms
Pathology
Neoplasms
Recurrence
Transitional Cell Carcinoma
Papillary Carcinoma
DNA
Karyotype
Cell Biology
Flow Cytometry
Epithelium
Urine
Technology
Biopsy
Light
Incidence

ASJC Scopus subject areas

  • Urology

Cite this

Weinstein, R. S., Coon, J. S., Schwartz, D., Miller, A. W., & Pauli, B. U. (1985). Pathology of superficial bladder cancer with emphasis on carcinoma in situ. Urology, 26(4 Suppl), 2-10.

Pathology of superficial bladder cancer with emphasis on carcinoma in situ. / Weinstein, Ronald S; Coon, J. S.; Schwartz, D.; Miller, A. W.; Pauli, B. U.

In: Urology, Vol. 26, No. 4 Suppl, 10.1985, p. 2-10.

Research output: Contribution to journalArticle

Weinstein, RS, Coon, JS, Schwartz, D, Miller, AW & Pauli, BU 1985, 'Pathology of superficial bladder cancer with emphasis on carcinoma in situ.', Urology, vol. 26, no. 4 Suppl, pp. 2-10.
Weinstein RS, Coon JS, Schwartz D, Miller AW, Pauli BU. Pathology of superficial bladder cancer with emphasis on carcinoma in situ. Urology. 1985 Oct;26(4 Suppl):2-10.
Weinstein, Ronald S ; Coon, J. S. ; Schwartz, D. ; Miller, A. W. ; Pauli, B. U. / Pathology of superficial bladder cancer with emphasis on carcinoma in situ. In: Urology. 1985 ; Vol. 26, No. 4 Suppl. pp. 2-10.
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