Pathophysiology and principles of management of the diabetic foot

David G Armstrong, Timothy K. Fisher, Brian Lepow, Matthew L. White, Joseph L Mills

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

INTRODUCTION The incidence of diabetes continues to grow at a staggering pace. The United States' Centers for Disease Control and Prevention estimate that 23.6 million people or 7.8% of the U.S. Population has diabetes, with 1.6 million new cases being diagnosed each year. These figures are even more astonishing when one considers worldwide estimates. Close to 4 million deaths in the 20–79 year old age group may be attributed to diabetes in 2010, accounting for 6.8% of global all-cause mortality in this age group. The number of people with diabetes worldwide is expected to reach 366 million people by 2030, more than double the estimated 177 million people affected with the disease in 2000. The increased disease prevalence is accompanied by an increase in associated comorbidities. The literature estimates that patients with diabetes have nearly a 25% lifetime risk of developing a foot ulcer with more than 50% of these ulcers becoming infected and requiring hospitalization. In fact, at least 20% of all diabetes-related hospital admissions are due to diabetic foot ulcers. Associated with foot ulcers and infection is the incidence of amputation. It has been conservatively reported that, worldwide, a major amputation takes place every 30 seconds with over 2500 limbs lost per day. At least 60% of all non-traumatic lower extremity amputations are related to complications of diabetes. People with diabetes who have had one amputation have a 68% risk of having another in the next 5 years and have a 50% mortality rate in the 5 years following the initial amputation.

Original languageEnglish (US)
Title of host publicationMechanisms of Vascular Disease: A Reference Book for Vascular Specialists
PublisherUniversity of Adelaide Press
Pages475-496
Number of pages22
ISBN (Print)9781922064004, 9780987171825
DOIs
StatePublished - Jan 1 2011

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Diabetic Foot
Amputation
Foot Ulcer
Age Groups
Mortality
Incidence
Diabetes Complications
Centers for Disease Control and Prevention (U.S.)
Ulcer
Comorbidity
Lower Extremity
Hospitalization
Extremities
Infection
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Armstrong, D. G., Fisher, T. K., Lepow, B., White, M. L., & Mills, J. L. (2011). Pathophysiology and principles of management of the diabetic foot. In Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists (pp. 475-496). University of Adelaide Press. https://doi.org/10.1017/UPO9781922064004.027

Pathophysiology and principles of management of the diabetic foot. / Armstrong, David G; Fisher, Timothy K.; Lepow, Brian; White, Matthew L.; Mills, Joseph L.

Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists. University of Adelaide Press, 2011. p. 475-496.

Research output: Chapter in Book/Report/Conference proceedingChapter

Armstrong, DG, Fisher, TK, Lepow, B, White, ML & Mills, JL 2011, Pathophysiology and principles of management of the diabetic foot. in Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists. University of Adelaide Press, pp. 475-496. https://doi.org/10.1017/UPO9781922064004.027
Armstrong DG, Fisher TK, Lepow B, White ML, Mills JL. Pathophysiology and principles of management of the diabetic foot. In Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists. University of Adelaide Press. 2011. p. 475-496 https://doi.org/10.1017/UPO9781922064004.027
Armstrong, David G ; Fisher, Timothy K. ; Lepow, Brian ; White, Matthew L. ; Mills, Joseph L. / Pathophysiology and principles of management of the diabetic foot. Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists. University of Adelaide Press, 2011. pp. 475-496
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