Abstract
The most common cancers, such as those affecting the breast, prostate, and lung have a strong predilection to metastasize to bone. Bone metastasis frequently results in pain, pathologic fractures, hypercalcemia, and spinal cord compression. Pain can have a devastating effect on the quality of life in advanced cancer patients and is a serious complication of cancer. Although significant advances are being made in cancer treatment and diagnosis, the basic neurobiology of bone cancer pain is poorly understood. New insights into the mechanisms that induce cancer pain now are coming from animal models. Chemicals derived from tumor cells, inflammatory cells, and cells derived from bone appear to be involved simultaneously in driving this frequently difficult-to-control pain state. Understanding the mechanisms involved in the pathophysiology of bone cancer pain will improve both our ability to provide mechanism-based therapies and the quality of life of cancer patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 15-24 |
| Number of pages | 10 |
| Journal | Journal of Supportive Oncology |
| Volume | 3 |
| Issue number | 1 |
| State | Published - Jan 2005 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Pathophysiology of bone cancer pain. / Sabino, Mary Ann C; Mantyh, Patrick W.
In: Journal of Supportive Oncology, Vol. 3, No. 1, 01.2005, p. 15-24.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pathophysiology of bone cancer pain
AU - Sabino, Mary Ann C
AU - Mantyh, Patrick W
PY - 2005/1
Y1 - 2005/1
N2 - The most common cancers, such as those affecting the breast, prostate, and lung have a strong predilection to metastasize to bone. Bone metastasis frequently results in pain, pathologic fractures, hypercalcemia, and spinal cord compression. Pain can have a devastating effect on the quality of life in advanced cancer patients and is a serious complication of cancer. Although significant advances are being made in cancer treatment and diagnosis, the basic neurobiology of bone cancer pain is poorly understood. New insights into the mechanisms that induce cancer pain now are coming from animal models. Chemicals derived from tumor cells, inflammatory cells, and cells derived from bone appear to be involved simultaneously in driving this frequently difficult-to-control pain state. Understanding the mechanisms involved in the pathophysiology of bone cancer pain will improve both our ability to provide mechanism-based therapies and the quality of life of cancer patients.
AB - The most common cancers, such as those affecting the breast, prostate, and lung have a strong predilection to metastasize to bone. Bone metastasis frequently results in pain, pathologic fractures, hypercalcemia, and spinal cord compression. Pain can have a devastating effect on the quality of life in advanced cancer patients and is a serious complication of cancer. Although significant advances are being made in cancer treatment and diagnosis, the basic neurobiology of bone cancer pain is poorly understood. New insights into the mechanisms that induce cancer pain now are coming from animal models. Chemicals derived from tumor cells, inflammatory cells, and cells derived from bone appear to be involved simultaneously in driving this frequently difficult-to-control pain state. Understanding the mechanisms involved in the pathophysiology of bone cancer pain will improve both our ability to provide mechanism-based therapies and the quality of life of cancer patients.
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UR - http://www.scopus.com/inward/citedby.url?scp=15544366136&partnerID=8YFLogxK
M3 - Article
C2 - 15724942
AN - SCOPUS:15544366136
VL - 3
SP - 15
EP - 24
JO - Journal of Supportive Oncology
JF - Journal of Supportive Oncology
SN - 1544-6794
IS - 1
ER -