Abstract
Several members of the SLC9A family of Na+/H+ exchangers are expressed in the gut, with varying expression patterns and cellular localization. Not only do they participate in the regulation of basic epithelial cell functions, including control of transepithelial Na+ absorption, intracellular pH (pHi), cell volume, and nutrient absorption, but also in cellular proliferation, migration, and apoptosis. In addition, they modulate the extracellular milieu to facilitate other nutrient absorption and to regulate the intestinal microbial microenvironment. Na+/H+ exchangers are frequent targets of inhibition in gastrointestinal pathologies, either by intrinsic factors (eg, bile acids, inflammatory mediators) or infectious agents and associated microbial toxins. Based on emerging evidence, disruption of Na+/H+ exchange activity via impaired expression or function of respective isoforms may contribute not only to local and systemic electrolyte imbalance, but also to the disease severity via multiple mechanisms. Here, we review the current state of knowledge about the roles Na+/H+ exchangers play in the pathogenesis of disorders of diverse origin and affecting a range of gastrointestinal tissues.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 27-40 |
| Number of pages | 14 |
| Journal | CMGH Cellular and Molecular Gastroenterology and Hepatology |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2017 |
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Keywords
- Barrett's Esophagus
- Diarrhea
- Epithelial Injury
- Epithelial Restitution
- Esophageal Adenocarcinoma
- Hypertension
- Infection
- Inflammation
- Inflammatory Bowel Disease
- Microbiota
ASJC Scopus subject areas
- Hepatology
- Gastroenterology
Cite this
Pathophysiology of Intestinal Na+/H+ Exchange. / Gurney, Michael A.; Laubitz, Daniel; Ghishan, Fayez K; Kiela, Pawel R.
In: CMGH Cellular and Molecular Gastroenterology and Hepatology, Vol. 3, No. 1, 01.01.2017, p. 27-40.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Pathophysiology of Intestinal Na+/H+ Exchange
AU - Gurney, Michael A.
AU - Laubitz, Daniel
AU - Ghishan, Fayez K
AU - Kiela, Pawel R
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Several members of the SLC9A family of Na+/H+ exchangers are expressed in the gut, with varying expression patterns and cellular localization. Not only do they participate in the regulation of basic epithelial cell functions, including control of transepithelial Na+ absorption, intracellular pH (pHi), cell volume, and nutrient absorption, but also in cellular proliferation, migration, and apoptosis. In addition, they modulate the extracellular milieu to facilitate other nutrient absorption and to regulate the intestinal microbial microenvironment. Na+/H+ exchangers are frequent targets of inhibition in gastrointestinal pathologies, either by intrinsic factors (eg, bile acids, inflammatory mediators) or infectious agents and associated microbial toxins. Based on emerging evidence, disruption of Na+/H+ exchange activity via impaired expression or function of respective isoforms may contribute not only to local and systemic electrolyte imbalance, but also to the disease severity via multiple mechanisms. Here, we review the current state of knowledge about the roles Na+/H+ exchangers play in the pathogenesis of disorders of diverse origin and affecting a range of gastrointestinal tissues.
AB - Several members of the SLC9A family of Na+/H+ exchangers are expressed in the gut, with varying expression patterns and cellular localization. Not only do they participate in the regulation of basic epithelial cell functions, including control of transepithelial Na+ absorption, intracellular pH (pHi), cell volume, and nutrient absorption, but also in cellular proliferation, migration, and apoptosis. In addition, they modulate the extracellular milieu to facilitate other nutrient absorption and to regulate the intestinal microbial microenvironment. Na+/H+ exchangers are frequent targets of inhibition in gastrointestinal pathologies, either by intrinsic factors (eg, bile acids, inflammatory mediators) or infectious agents and associated microbial toxins. Based on emerging evidence, disruption of Na+/H+ exchange activity via impaired expression or function of respective isoforms may contribute not only to local and systemic electrolyte imbalance, but also to the disease severity via multiple mechanisms. Here, we review the current state of knowledge about the roles Na+/H+ exchangers play in the pathogenesis of disorders of diverse origin and affecting a range of gastrointestinal tissues.
KW - Barrett's Esophagus
KW - Diarrhea
KW - Epithelial Injury
KW - Epithelial Restitution
KW - Esophageal Adenocarcinoma
KW - Hypertension
KW - Infection
KW - Inflammation
KW - Inflammatory Bowel Disease
KW - Microbiota
UR - http://www.scopus.com/inward/record.url?scp=85007397274&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85007397274&partnerID=8YFLogxK
U2 - 10.1016/j.jcmgh.2016.09.010
DO - 10.1016/j.jcmgh.2016.09.010
M3 - Review article
AN - SCOPUS:85007397274
VL - 3
SP - 27
EP - 40
JO - Cellular and Molecular Gastroenterology and Hepatology
JF - Cellular and Molecular Gastroenterology and Hepatology
SN - 2352-345X
IS - 1
ER -