Abstract
Pulmonary hypertension is not a disease, per se, but a hemodynamic abnormality that is common to a variety of conditions. The primary pulmonary hypertension (PPH) Registry initiated by the National Heart, Lung and Blood Institute in 1981 defined pulmonary hypertension as a mean pulmonary arterial pressure (PAP) greater than 25 mm Hg at rest or 30 mm Hg on exercise (1). It should be recognized, however, that PAP varies with age. Between days 1 and 3 of neonatal life the mean PAP falls, from 6 to 45 years of age it remains fairly constant, and it increases beyond 60 to 83 years of age. Consequently, the mean plus 2 SD gives an upper limit of normal of 20 mm Hg from childhood to approximately 60 years of age. The upper limit for pulmonary vascular resistance (PVR) index [(PAP wedge pressure)/cardiac index] in normal subjects increases from approximately 2.8 (610 years) to 3.2 (32 to 45 years) to 4.6 mm Hg/L/min/m2 (60-83 years).
| Original language | English (US) |
|---|---|
| Title of host publication | Respiratory-Circulatory Interactions in Health and Disease |
| Publisher | CRC Press |
| Pages | 447-478 |
| Number of pages | 32 |
| ISBN (Electronic) | 9780824741747 |
| ISBN (Print) | 9780824704742 |
| State | Published - Jan 1 2001 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Pathophysiology of pulmonary hypertension. / Yuan, Jason; Rubin, Lewis J.
Respiratory-Circulatory Interactions in Health and Disease. CRC Press, 2001. p. 447-478.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Pathophysiology of pulmonary hypertension
AU - Yuan, Jason
AU - Rubin, Lewis J.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Pulmonary hypertension is not a disease, per se, but a hemodynamic abnormality that is common to a variety of conditions. The primary pulmonary hypertension (PPH) Registry initiated by the National Heart, Lung and Blood Institute in 1981 defined pulmonary hypertension as a mean pulmonary arterial pressure (PAP) greater than 25 mm Hg at rest or 30 mm Hg on exercise (1). It should be recognized, however, that PAP varies with age. Between days 1 and 3 of neonatal life the mean PAP falls, from 6 to 45 years of age it remains fairly constant, and it increases beyond 60 to 83 years of age. Consequently, the mean plus 2 SD gives an upper limit of normal of 20 mm Hg from childhood to approximately 60 years of age. The upper limit for pulmonary vascular resistance (PVR) index [(PAP wedge pressure)/cardiac index] in normal subjects increases from approximately 2.8 (610 years) to 3.2 (32 to 45 years) to 4.6 mm Hg/L/min/m2 (60-83 years).
AB - Pulmonary hypertension is not a disease, per se, but a hemodynamic abnormality that is common to a variety of conditions. The primary pulmonary hypertension (PPH) Registry initiated by the National Heart, Lung and Blood Institute in 1981 defined pulmonary hypertension as a mean pulmonary arterial pressure (PAP) greater than 25 mm Hg at rest or 30 mm Hg on exercise (1). It should be recognized, however, that PAP varies with age. Between days 1 and 3 of neonatal life the mean PAP falls, from 6 to 45 years of age it remains fairly constant, and it increases beyond 60 to 83 years of age. Consequently, the mean plus 2 SD gives an upper limit of normal of 20 mm Hg from childhood to approximately 60 years of age. The upper limit for pulmonary vascular resistance (PVR) index [(PAP wedge pressure)/cardiac index] in normal subjects increases from approximately 2.8 (610 years) to 3.2 (32 to 45 years) to 4.6 mm Hg/L/min/m2 (60-83 years).
UR - http://www.scopus.com/inward/record.url?scp=0002329827&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0002329827&partnerID=8YFLogxK
M3 - Chapter
AN - SCOPUS:0002329827
SN - 9780824704742
SP - 447
EP - 478
BT - Respiratory-Circulatory Interactions in Health and Disease
PB - CRC Press
ER -