Pathophysiology of pulmonary hypertension

Jason Yuan, Lewis J. Rubin

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Citations (Scopus)

Abstract

Pulmonary hypertension is not a disease, per se, but a hemodynamic abnormality that is common to a variety of conditions. The primary pulmonary hypertension (PPH) Registry initiated by the National Heart, Lung and Blood Institute in 1981 defined pulmonary hypertension as a mean pulmonary arterial pressure (PAP) greater than 25 mm Hg at rest or 30 mm Hg on exercise (1). It should be recognized, however, that PAP varies with age. Between days 1 and 3 of neonatal life the mean PAP falls, from 6 to 45 years of age it remains fairly constant, and it increases beyond 60 to 83 years of age. Consequently, the mean plus 2 SD gives an upper limit of normal of 20 mm Hg from childhood to approximately 60 years of age. The upper limit for pulmonary vascular resistance (PVR) index [(PAP wedge pressure)/cardiac index] in normal subjects increases from approximately 2.8 (610 years) to 3.2 (32 to 45 years) to 4.6 mm Hg/L/min/m2 (60-83 years).

Original languageEnglish (US)
Title of host publicationRespiratory-Circulatory Interactions in Health and Disease
PublisherCRC Press
Pages447-478
Number of pages32
ISBN (Electronic)9780824741747
ISBN (Print)9780824704742
StatePublished - Jan 1 2001
Externally publishedYes

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Pulmonary Hypertension
Arterial Pressure
Lung
National Heart, Lung, and Blood Institute (U.S.)
Pulmonary Wedge Pressure
Vascular Resistance
Registries
Hemodynamics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Yuan, J., & Rubin, L. J. (2001). Pathophysiology of pulmonary hypertension. In Respiratory-Circulatory Interactions in Health and Disease (pp. 447-478). CRC Press.

Pathophysiology of pulmonary hypertension. / Yuan, Jason; Rubin, Lewis J.

Respiratory-Circulatory Interactions in Health and Disease. CRC Press, 2001. p. 447-478.

Research output: Chapter in Book/Report/Conference proceedingChapter

Yuan, J & Rubin, LJ 2001, Pathophysiology of pulmonary hypertension. in Respiratory-Circulatory Interactions in Health and Disease. CRC Press, pp. 447-478.
Yuan J, Rubin LJ. Pathophysiology of pulmonary hypertension. In Respiratory-Circulatory Interactions in Health and Disease. CRC Press. 2001. p. 447-478
Yuan, Jason ; Rubin, Lewis J. / Pathophysiology of pulmonary hypertension. Respiratory-Circulatory Interactions in Health and Disease. CRC Press, 2001. pp. 447-478
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