Pathophysiology of tumour-induced microangiopathic haemolytic anaemia

Pavani Chalasani, Jennifer M. Segar, Marilyn Marron, Alison T Stopeck

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Cancer-associated microangiopathic haemolytic anaemia (CA-MAHA) is a syndrome characterised by Coombsnegative haemolytic anaemia and thrombocytopenia. It is primarily seen in advanced solid tumours and is distinct from thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome. Diagnosis is often delayed and patients have a high mortality. We present the case of CA-MAHA in a patient with metastatic breast cancer treated successfully with early initiation of chemotherapy. In addition, we report longitudinal laboratory evaluation of circulating tumour cells and microparticles and suggest a hypothesis for the mechanism behind CAMAHA.

Original languageEnglish (US)
Article number213521
JournalBMJ Case Reports
Publication statusPublished - Jan 7 2016


ASJC Scopus subject areas

  • Medicine(all)

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