Patient With Hypofibrinolysis-mediated Thromboembolism Converted to a Hypercoagulable/Hyperfibrinolytic State via Ventricular Assist Device Placement

Vance G Nielsen, James K. Kirklin, William L. Holman, James F. George, Truitt C. Ellis, Brad L. Steenwyk

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Mechanical circulatory support with ventricular assist devices (VADs) for end-stage heart failure has been a focus of intense interest for nearly four decades. Despite improvements in VAD design and biomaterial composition, it is common to administer anti-coagulation (e.g., warfarin, anti-platelet agents) to prevent both device thrombosis and thromboembolism. We present a patient with pre-operative thrombophilia (pulmonary embolism, intracardiac thrombus) and hypofibrinolysis, who subsequently developed hypercoagulability with hyperfibrinolysis with normalization of clot lifespan after left VAD placement. Such complex patient-VAD-hemostatic-state interactions serve as the rationale for continuing investigation of the effects of mechanical circulation on the fibrinolytic system and thrombophilia.

Original languageEnglish (US)
Pages (from-to)1169-1171
Number of pages3
JournalJournal of Heart and Lung Transplantation
Volume27
Issue number10
DOIs
StatePublished - Oct 2008
Externally publishedYes

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Heart-Assist Devices
Thromboembolism
Thrombophilia
Thrombosis
Equipment Design
Biocompatible Materials
Hemostatics
Warfarin
Pulmonary Embolism
Blood Platelets
Heart Failure
Equipment and Supplies

ASJC Scopus subject areas

  • Transplantation
  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Patient With Hypofibrinolysis-mediated Thromboembolism Converted to a Hypercoagulable/Hyperfibrinolytic State via Ventricular Assist Device Placement. / Nielsen, Vance G; Kirklin, James K.; Holman, William L.; George, James F.; Ellis, Truitt C.; Steenwyk, Brad L.

In: Journal of Heart and Lung Transplantation, Vol. 27, No. 10, 10.2008, p. 1169-1171.

Research output: Contribution to journalArticle

Nielsen, Vance G ; Kirklin, James K. ; Holman, William L. ; George, James F. ; Ellis, Truitt C. ; Steenwyk, Brad L. / Patient With Hypofibrinolysis-mediated Thromboembolism Converted to a Hypercoagulable/Hyperfibrinolytic State via Ventricular Assist Device Placement. In: Journal of Heart and Lung Transplantation. 2008 ; Vol. 27, No. 10. pp. 1169-1171.
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