Patients with condyloma acuminatum exhibit decreased interleukin-2 and interferon gamma production and depressed natural killer activity

Roberto Cauda, Stephen K. Tyring, Carlo E. Grossi, Arabella B. Tilden, Kenneth D. Hatch, W. Mitchell Sams, Samuel Baron, Richard J. Whitley

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Peripheral blood mononuclear cells were obtained from 20 untreated condyloma acuminatum patients and from an equal number of sex- and age-matched controls and assayed for cell surface antigen expression, natural killer activity, and lymphokine production. Patient peripheral blood mononuclear cells had significantly lower helper-to-suppressor T-cell ratios (Leu3/Leu2) (p<0.05) and significantly higher percentages of Leu 2+ Tac+ cells (activated suppressor/cytotoxic cells) (P<0.05) and Leu 2+ OKM1+ cells (suppressor cells) (P<0.01). Natural killer activity of condyloma acuminatum patients was significantly lower (P<0.05) than that of controls. Production of interleukin-2 and interferon gamma, but not interferon alpha, was significantly (P<0.01) decreased in condyloma acuminatum patients. There was an inverse correlation between the in vitro production of interleukin-2 and interferon gamma and the percentage of Leu 2+ OKM1+ cells (suppressor) (P<0.01). Thus, patients with condyloma acuminatum differ from controls by demonstrating (1) decreased natural killer-cell activity, (2) decreased production of lymphokines which enhance natural killer-cell activity (i.e., interferon gamma and interleukin-2), and (3) an increased proportion of T cells with a suppressor phenotype.

Original languageEnglish (US)
Pages (from-to)304-311
Number of pages8
JournalJournal of Clinical Immunology
Volume7
Issue number4
DOIs
StatePublished - Jul 1 1987

Keywords

  • Condyloma acuminatum
  • interferon gamma
  • interleukin-2
  • natural killer cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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