Patients with condyloma acuminatum exhibit decreased interleukin-2 and interferon gamma production and depressed natural killer activity

Roberto Cauda, Stephen K. Tyring, Carlo E. Grossi, Arabella B. Tilden, Kenneth D Hatch, W. Mitchell Sams, Samuel Baron, Richard J. Whitley

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Peripheral blood mononuclear cells were obtained from 20 untreated condyloma acuminatum patients and from an equal number of sex- and age-matched controls and assayed for cell surface antigen expression, natural killer activity, and lymphokine production. Patient peripheral blood mononuclear cells had significantly lower helper-to-suppressor T-cell ratios (Leu3/Leu2) (p<0.05) and significantly higher percentages of Leu 2+ Tac+ cells (activated suppressor/cytotoxic cells) (P<0.05) and Leu 2+ OKM1+ cells (suppressor cells) (P<0.01). Natural killer activity of condyloma acuminatum patients was significantly lower (P<0.05) than that of controls. Production of interleukin-2 and interferon gamma, but not interferon alpha, was significantly (P<0.01) decreased in condyloma acuminatum patients. There was an inverse correlation between the in vitro production of interleukin-2 and interferon gamma and the percentage of Leu 2+ OKM1+ cells (suppressor) (P<0.01). Thus, patients with condyloma acuminatum differ from controls by demonstrating (1) decreased natural killer-cell activity, (2) decreased production of lymphokines which enhance natural killer-cell activity (i.e., interferon gamma and interleukin-2), and (3) an increased proportion of T cells with a suppressor phenotype.

Original languageEnglish (US)
Pages (from-to)304-311
Number of pages8
JournalJournal of Clinical Immunology
Volume7
Issue number4
DOIs
Publication statusPublished - Jul 1987
Externally publishedYes

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Keywords

  • Condyloma acuminatum
  • interferon gamma
  • interleukin-2
  • natural killer cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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