Pattern of failure following chemoradiation for locally advanced non-small cell lung cancer: Potential role for stereotactic body radiotherapy

Nam P. Nguyen, Maria Bishop, Thomas J. Borok, James Welsh, Russell J Hamilton, Deirdre Cohen, L. Y M Nguyen, Vinh Hung Vincent

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Standard of care for locally advanced non-small cell lung cancer has been concurrent chemoradiation. However, optimal chemotherapy regimen, radiation therapy dose and treatment volume have not been clearly defined despite 30 years of controlled clinical trials. This review analyzes survival and failure pattern reported from randomized studies of chemoradiation for non-small cell lung cancer. Despite introduction of new chemotherapy agents, survival remained poor; rates of both locoregional failures and distant metastasis remained high. The current radiation dose appears insufficient to reliably establish local control. Stereotactic body radiotherapy may allow radiation dose escalation and should be tested in future clinical trials.

Original languageEnglish (US)
Pages (from-to)953-962
Number of pages10
JournalAnticancer Research
Volume30
Issue number3
StatePublished - Mar 2010

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Radiosurgery
Non-Small Cell Lung Carcinoma
Radiation
Drug Therapy
Controlled Clinical Trials
Standard of Care
Survival Analysis
Radiotherapy
Clinical Trials
Neoplasm Metastasis
Therapeutics

Keywords

  • Chemoradiation
  • Locally advanced
  • Non-small cell lung cancer
  • Pattern of failure

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pattern of failure following chemoradiation for locally advanced non-small cell lung cancer : Potential role for stereotactic body radiotherapy. / Nguyen, Nam P.; Bishop, Maria; Borok, Thomas J.; Welsh, James; Hamilton, Russell J; Cohen, Deirdre; Nguyen, L. Y M; Vincent, Vinh Hung.

In: Anticancer Research, Vol. 30, No. 3, 03.2010, p. 953-962.

Research output: Contribution to journalArticle

Nguyen, NP, Bishop, M, Borok, TJ, Welsh, J, Hamilton, RJ, Cohen, D, Nguyen, LYM & Vincent, VH 2010, 'Pattern of failure following chemoradiation for locally advanced non-small cell lung cancer: Potential role for stereotactic body radiotherapy', Anticancer Research, vol. 30, no. 3, pp. 953-962.
Nguyen, Nam P. ; Bishop, Maria ; Borok, Thomas J. ; Welsh, James ; Hamilton, Russell J ; Cohen, Deirdre ; Nguyen, L. Y M ; Vincent, Vinh Hung. / Pattern of failure following chemoradiation for locally advanced non-small cell lung cancer : Potential role for stereotactic body radiotherapy. In: Anticancer Research. 2010 ; Vol. 30, No. 3. pp. 953-962.
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