Pauses, steps, and the mechanism of contraction.

G. H. Pollack, H. L. Granzier, A. Mattiazzi, C. Trombitás, A. Periasamy, P. H. Baatsen, D. H. Burns

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Despite widespread controversy still surrounding the phenomenon, stepwise shortening has now been confirmed by five independent methods in this laboratory, and by several other methods in different laboratories. In this paper we offer preliminary evidence obtained with the most recent method--measurement of 'isotonic muscle length transients'. We find that the muscle length inflections observed after quick release to an isotonic load correspond to pauses and steps at the sarcomere level. Thus, pauses and steps are reflected not only in sarcomere length and segment length signals, but in the muscle length signal as well. We review several of the more illuminating features of stepwise shortening, as well as new ultrastructural observations which, taken together, point to an hypothesis for the generation of steps. The steps may be generated by shortening of one or another of the sarcomere's filaments: connecting filaments in the unactivated myofibril and thick filaments in the activated myofibril. Supporting evidence is considered.

Original languageEnglish (US)
Pages (from-to)617-642
Number of pages26
JournalAdvances in experimental medicine and biology
Volume226
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Pollack, G. H., Granzier, H. L., Mattiazzi, A., Trombitás, C., Periasamy, A., Baatsen, P. H., & Burns, D. H. (1988). Pauses, steps, and the mechanism of contraction. Advances in experimental medicine and biology, 226, 617-642.