Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015

J. Bousquet, J. M. Anto, M. Akdis, C. Auffray, T. Keil, I. Momas, D. S. Postma, R. Valenta, M. Wickman, A. Cambon-Thomsen, T. Haahtela, B. N. Lambrecht, K. C. Lodrup Carlsen, G. H. Koppelman, J. Sunyer, T. Zuberbier, I. Annesi-Maesano, A. Arno, C. Bindslev-Jensen, G. De CarloF. Forastiere, J. Heinrich, M. L. Kowalski, D. Maier, E. Melén, S. Palkonen, H. A. Smit, M. Standl, J. Wright, A. Asarnoj, M. Benet, N. Ballardini, J. Garcia-Aymerich, U. Gehring, S. Guerra, C. Hohman, I. Kull, C. Lupinek, M. Pinart, I. Skrindo, M. Westman, D. Smagghe, C. Akdis, R. Albang, V. Anastasova, N. Anderson, C. Bachert, S. Ballereau, F. Ballester, X. Basagana, A. Bedbrook, A. Bergstrom, A. von Berg, B. Brunekreef, E. Burte, K. H. Carlsen, L. Chatzi, J. M. Coquet, M. Curin, P. Demoly, E. Eller, M. P. Fantini, B. Gerhard, H. Hammad, L. von Hertzen, V. Hovland, B. Jacquemin, J. Just, T. Keller, M. Kerkhof, R. Kiss, M. Kogevinas, S. Koletzko, S. Lau, I. Lehmann, N. Lemonnier, R. McEachan, M. Mäkelä, J. Mestres, E. Minina, P. Mowinckel, R. Nadif, M. Nawijn, S. Oddie, J. Pellet, I. Pin, D. Porta, F. Rancière, A. Rial-Sebbag, Y. Saeys, M. J. Schuijs, V. Siroux, C. G. Tischer, M. Torrent, R. Varraso, J. De Vocht, K. Wenger, S. Wieser, C. Xu

Research output: Contribution to journalReview article

49 Citations (Scopus)

Abstract

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.

Original languageEnglish (US)
Pages (from-to)1513-1525
Number of pages13
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume71
Issue number11
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Fingerprint

Precision Medicine
Systems Biology
Systems Analysis
Hypersensitivity
Immunoglobulin E
Comorbidity
Environmental Exposure
Epigenomics
Ethics
Parturition
Research
Population

Keywords

  • asthma
  • IgE
  • multimorbidity
  • polysensitization
  • rhinitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Paving the way of systems biology and precision medicine in allergic diseases : the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015. / Bousquet, J.; Anto, J. M.; Akdis, M.; Auffray, C.; Keil, T.; Momas, I.; Postma, D. S.; Valenta, R.; Wickman, M.; Cambon-Thomsen, A.; Haahtela, T.; Lambrecht, B. N.; Lodrup Carlsen, K. C.; Koppelman, G. H.; Sunyer, J.; Zuberbier, T.; Annesi-Maesano, I.; Arno, A.; Bindslev-Jensen, C.; De Carlo, G.; Forastiere, F.; Heinrich, J.; Kowalski, M. L.; Maier, D.; Melén, E.; Palkonen, S.; Smit, H. A.; Standl, M.; Wright, J.; Asarnoj, A.; Benet, M.; Ballardini, N.; Garcia-Aymerich, J.; Gehring, U.; Guerra, S.; Hohman, C.; Kull, I.; Lupinek, C.; Pinart, M.; Skrindo, I.; Westman, M.; Smagghe, D.; Akdis, C.; Albang, R.; Anastasova, V.; Anderson, N.; Bachert, C.; Ballereau, S.; Ballester, F.; Basagana, X.; Bedbrook, A.; Bergstrom, A.; von Berg, A.; Brunekreef, B.; Burte, E.; Carlsen, K. H.; Chatzi, L.; Coquet, J. M.; Curin, M.; Demoly, P.; Eller, E.; Fantini, M. P.; Gerhard, B.; Hammad, H.; von Hertzen, L.; Hovland, V.; Jacquemin, B.; Just, J.; Keller, T.; Kerkhof, M.; Kiss, R.; Kogevinas, M.; Koletzko, S.; Lau, S.; Lehmann, I.; Lemonnier, N.; McEachan, R.; Mäkelä, M.; Mestres, J.; Minina, E.; Mowinckel, P.; Nadif, R.; Nawijn, M.; Oddie, S.; Pellet, J.; Pin, I.; Porta, D.; Rancière, F.; Rial-Sebbag, A.; Saeys, Y.; Schuijs, M. J.; Siroux, V.; Tischer, C. G.; Torrent, M.; Varraso, R.; De Vocht, J.; Wenger, K.; Wieser, S.; Xu, C.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 71, No. 11, 01.11.2016, p. 1513-1525.

Research output: Contribution to journalReview article

Bousquet, J, Anto, JM, Akdis, M, Auffray, C, Keil, T, Momas, I, Postma, DS, Valenta, R, Wickman, M, Cambon-Thomsen, A, Haahtela, T, Lambrecht, BN, Lodrup Carlsen, KC, Koppelman, GH, Sunyer, J, Zuberbier, T, Annesi-Maesano, I, Arno, A, Bindslev-Jensen, C, De Carlo, G, Forastiere, F, Heinrich, J, Kowalski, ML, Maier, D, Melén, E, Palkonen, S, Smit, HA, Standl, M, Wright, J, Asarnoj, A, Benet, M, Ballardini, N, Garcia-Aymerich, J, Gehring, U, Guerra, S, Hohman, C, Kull, I, Lupinek, C, Pinart, M, Skrindo, I, Westman, M, Smagghe, D, Akdis, C, Albang, R, Anastasova, V, Anderson, N, Bachert, C, Ballereau, S, Ballester, F, Basagana, X, Bedbrook, A, Bergstrom, A, von Berg, A, Brunekreef, B, Burte, E, Carlsen, KH, Chatzi, L, Coquet, JM, Curin, M, Demoly, P, Eller, E, Fantini, MP, Gerhard, B, Hammad, H, von Hertzen, L, Hovland, V, Jacquemin, B, Just, J, Keller, T, Kerkhof, M, Kiss, R, Kogevinas, M, Koletzko, S, Lau, S, Lehmann, I, Lemonnier, N, McEachan, R, Mäkelä, M, Mestres, J, Minina, E, Mowinckel, P, Nadif, R, Nawijn, M, Oddie, S, Pellet, J, Pin, I, Porta, D, Rancière, F, Rial-Sebbag, A, Saeys, Y, Schuijs, MJ, Siroux, V, Tischer, CG, Torrent, M, Varraso, R, De Vocht, J, Wenger, K, Wieser, S & Xu, C 2016, 'Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015', Allergy: European Journal of Allergy and Clinical Immunology, vol. 71, no. 11, pp. 1513-1525. https://doi.org/10.1111/all.12880
Bousquet, J. ; Anto, J. M. ; Akdis, M. ; Auffray, C. ; Keil, T. ; Momas, I. ; Postma, D. S. ; Valenta, R. ; Wickman, M. ; Cambon-Thomsen, A. ; Haahtela, T. ; Lambrecht, B. N. ; Lodrup Carlsen, K. C. ; Koppelman, G. H. ; Sunyer, J. ; Zuberbier, T. ; Annesi-Maesano, I. ; Arno, A. ; Bindslev-Jensen, C. ; De Carlo, G. ; Forastiere, F. ; Heinrich, J. ; Kowalski, M. L. ; Maier, D. ; Melén, E. ; Palkonen, S. ; Smit, H. A. ; Standl, M. ; Wright, J. ; Asarnoj, A. ; Benet, M. ; Ballardini, N. ; Garcia-Aymerich, J. ; Gehring, U. ; Guerra, S. ; Hohman, C. ; Kull, I. ; Lupinek, C. ; Pinart, M. ; Skrindo, I. ; Westman, M. ; Smagghe, D. ; Akdis, C. ; Albang, R. ; Anastasova, V. ; Anderson, N. ; Bachert, C. ; Ballereau, S. ; Ballester, F. ; Basagana, X. ; Bedbrook, A. ; Bergstrom, A. ; von Berg, A. ; Brunekreef, B. ; Burte, E. ; Carlsen, K. H. ; Chatzi, L. ; Coquet, J. M. ; Curin, M. ; Demoly, P. ; Eller, E. ; Fantini, M. P. ; Gerhard, B. ; Hammad, H. ; von Hertzen, L. ; Hovland, V. ; Jacquemin, B. ; Just, J. ; Keller, T. ; Kerkhof, M. ; Kiss, R. ; Kogevinas, M. ; Koletzko, S. ; Lau, S. ; Lehmann, I. ; Lemonnier, N. ; McEachan, R. ; Mäkelä, M. ; Mestres, J. ; Minina, E. ; Mowinckel, P. ; Nadif, R. ; Nawijn, M. ; Oddie, S. ; Pellet, J. ; Pin, I. ; Porta, D. ; Rancière, F. ; Rial-Sebbag, A. ; Saeys, Y. ; Schuijs, M. J. ; Siroux, V. ; Tischer, C. G. ; Torrent, M. ; Varraso, R. ; De Vocht, J. ; Wenger, K. ; Wieser, S. ; Xu, C. / Paving the way of systems biology and precision medicine in allergic diseases : the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015. In: Allergy: European Journal of Allergy and Clinical Immunology. 2016 ; Vol. 71, No. 11. pp. 1513-1525.
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title = "Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015",
abstract = "MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.",
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TY - JOUR

T1 - Paving the way of systems biology and precision medicine in allergic diseases

T2 - the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015

AU - Bousquet, J.

AU - Anto, J. M.

AU - Akdis, M.

AU - Auffray, C.

AU - Keil, T.

AU - Momas, I.

AU - Postma, D. S.

AU - Valenta, R.

AU - Wickman, M.

AU - Cambon-Thomsen, A.

AU - Haahtela, T.

AU - Lambrecht, B. N.

AU - Lodrup Carlsen, K. C.

AU - Koppelman, G. H.

AU - Sunyer, J.

AU - Zuberbier, T.

AU - Annesi-Maesano, I.

AU - Arno, A.

AU - Bindslev-Jensen, C.

AU - De Carlo, G.

AU - Forastiere, F.

AU - Heinrich, J.

AU - Kowalski, M. L.

AU - Maier, D.

AU - Melén, E.

AU - Palkonen, S.

AU - Smit, H. A.

AU - Standl, M.

AU - Wright, J.

AU - Asarnoj, A.

AU - Benet, M.

AU - Ballardini, N.

AU - Garcia-Aymerich, J.

AU - Gehring, U.

AU - Guerra, S.

AU - Hohman, C.

AU - Kull, I.

AU - Lupinek, C.

AU - Pinart, M.

AU - Skrindo, I.

AU - Westman, M.

AU - Smagghe, D.

AU - Akdis, C.

AU - Albang, R.

AU - Anastasova, V.

AU - Anderson, N.

AU - Bachert, C.

AU - Ballereau, S.

AU - Ballester, F.

AU - Basagana, X.

AU - Bedbrook, A.

AU - Bergstrom, A.

AU - von Berg, A.

AU - Brunekreef, B.

AU - Burte, E.

AU - Carlsen, K. H.

AU - Chatzi, L.

AU - Coquet, J. M.

AU - Curin, M.

AU - Demoly, P.

AU - Eller, E.

AU - Fantini, M. P.

AU - Gerhard, B.

AU - Hammad, H.

AU - von Hertzen, L.

AU - Hovland, V.

AU - Jacquemin, B.

AU - Just, J.

AU - Keller, T.

AU - Kerkhof, M.

AU - Kiss, R.

AU - Kogevinas, M.

AU - Koletzko, S.

AU - Lau, S.

AU - Lehmann, I.

AU - Lemonnier, N.

AU - McEachan, R.

AU - Mäkelä, M.

AU - Mestres, J.

AU - Minina, E.

AU - Mowinckel, P.

AU - Nadif, R.

AU - Nawijn, M.

AU - Oddie, S.

AU - Pellet, J.

AU - Pin, I.

AU - Porta, D.

AU - Rancière, F.

AU - Rial-Sebbag, A.

AU - Saeys, Y.

AU - Schuijs, M. J.

AU - Siroux, V.

AU - Tischer, C. G.

AU - Torrent, M.

AU - Varraso, R.

AU - De Vocht, J.

AU - Wenger, K.

AU - Wieser, S.

AU - Xu, C.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.

AB - MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.

KW - asthma

KW - IgE

KW - multimorbidity

KW - polysensitization

KW - rhinitis

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U2 - 10.1111/all.12880

DO - 10.1111/all.12880

M3 - Review article

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VL - 71

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EP - 1525

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

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