Pediatric multiple organ dysfunction syndrome

Promising therapies

Allan Doctor, Jerry Zimmerman, Michael Agus, Surender Rajasekaran, Juliane Bubeck Wardenburg, James Fortenberry, Anne Zajicek, Emma Mairson, Katri V Typpo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: To describe the state of the science, identify knowledge gaps, and offer potential future research questions regarding promising therapies for children with multiple organ dysfunction syndrome presented during the Eunice Kennedy Shriver National Institute of Child Health and Human Development Workshop on Pediatric Multiple Organ Dysfunction Syndrome (March 26-27, 2015). Data Sources: Literature review, research data, and expert opinion. Study Selection: Not applicable. Data Extraction: Moderated by an expert from the field, issues relevant to the association of multiple organ dysfunction syndrome with a variety of conditions were presented, discussed, and debated with a focus on identifying knowledge gaps and research priorities. Data Synthesis: Summary of presentations and discussion supported and supplemented by relevant literature. Conclusions: Among critically ill children, multiple organ dysfunction syndrome is relatively common and associated with significant morbidity and mortality. For outcomes to improve, effective therapies aimed at preventing and treating this condition must be discovered and rigorously evaluated. In this article, a number of potential opportunities to enhance current care are highlighted including the need for a better understanding of the pharmacokinetics and pharmacodynamics of medications, the effect of early and optimized nutrition, and the impact of effective glucose control in the setting of multiple organ dysfunction syndrome. Additionally, a handful of the promising therapies either currently being implemented or developed are described. These include extracorporeal therapies, anticytokine therapies, antitoxin treatments, antioxidant approaches, and multiple forms of exogenous steroids. For the field to advance, promising therapies and other therapies must be assessed in rigorous manner and implemented accordingly.

Original languageEnglish (US)
Pages (from-to)S67-S82
JournalPediatric Critical Care Medicine
Volume18
Issue number3
DOIs
StatePublished - 2017

Fingerprint

Multiple Organ Failure
Pediatrics
Therapeutics
National Institute of Child Health and Human Development (U.S.)
Antitoxins
Information Storage and Retrieval
Expert Testimony
Research
Critical Illness
Pharmacokinetics
Antioxidants
Steroids
Morbidity
Education
Glucose
Mortality

Keywords

  • Antioxidant
  • Glycemic control
  • Multiple organ dysfunction syndrome
  • Nutrition
  • Pediatrics
  • Steriods

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Critical Care and Intensive Care Medicine

Cite this

Doctor, A., Zimmerman, J., Agus, M., Rajasekaran, S., Wardenburg, J. B., Fortenberry, J., ... Typpo, K. V. (2017). Pediatric multiple organ dysfunction syndrome: Promising therapies. Pediatric Critical Care Medicine, 18(3), S67-S82. https://doi.org/10.1097/PCC.0000000000001053

Pediatric multiple organ dysfunction syndrome : Promising therapies. / Doctor, Allan; Zimmerman, Jerry; Agus, Michael; Rajasekaran, Surender; Wardenburg, Juliane Bubeck; Fortenberry, James; Zajicek, Anne; Mairson, Emma; Typpo, Katri V.

In: Pediatric Critical Care Medicine, Vol. 18, No. 3, 2017, p. S67-S82.

Research output: Contribution to journalArticle

Doctor, A, Zimmerman, J, Agus, M, Rajasekaran, S, Wardenburg, JB, Fortenberry, J, Zajicek, A, Mairson, E & Typpo, KV 2017, 'Pediatric multiple organ dysfunction syndrome: Promising therapies', Pediatric Critical Care Medicine, vol. 18, no. 3, pp. S67-S82. https://doi.org/10.1097/PCC.0000000000001053
Doctor A, Zimmerman J, Agus M, Rajasekaran S, Wardenburg JB, Fortenberry J et al. Pediatric multiple organ dysfunction syndrome: Promising therapies. Pediatric Critical Care Medicine. 2017;18(3):S67-S82. https://doi.org/10.1097/PCC.0000000000001053
Doctor, Allan ; Zimmerman, Jerry ; Agus, Michael ; Rajasekaran, Surender ; Wardenburg, Juliane Bubeck ; Fortenberry, James ; Zajicek, Anne ; Mairson, Emma ; Typpo, Katri V. / Pediatric multiple organ dysfunction syndrome : Promising therapies. In: Pediatric Critical Care Medicine. 2017 ; Vol. 18, No. 3. pp. S67-S82.
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