PentaLyte decreases lung injury after aortic occlusion-reperfusion

R. N. Axon, M. S. Baird, J. D. Lang, A. E. Brix, Vance G Nielsen

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Lung injury often occurs after hepatoenteric ischemia, with xanthine oxidase (XO, an oxidant-generating enzyme), released from reperfusing liver and intestines, mediating a significant component of this injury. Since pentastarch administration decreases intestinal reperfusion injury, we determined whether resuscitation with PentaLyte (a pentastarch-containing solution) would decrease hepatoenteric reperfusion injury, xanthine oxidase release, and concomitant lung injury after aortic occlusion-reperfusion. Aortic occlusion was established in rabbits for 40 min, and was followed by 3 h of reperfusion, during which either PentaLyte or lactated Ringer's solution-based resuscitation was administered. Sham-operated animals served as controls. Hepatoenteric reperfusion injury, as manifested by release of the enzyme aspartate aminotransferase and decreased gastric intramucosal pH, was significantly (p < 0.0167) attenuated by PentaLyte administration after aortic occlusion-reperfusion, as compared with its occurrence in animals given lactated Ringer's solution. The release of XO after aortic occlusion- reperfusion was 4-fold smaller after PentaLyte administration than after resuscitation with lactated Ringer's solution (p < 0.05). Pulmonary injury, as defined by an increase in bronchoalveolar lavage fluid (BALF) protein content and lactate dehydrogenase (LDH) activity, was 4-fold less after PentaLyte administration following aortic occlusion-reperfusion than after administration of lactated Ringer's solution (p < 0.05). We conclude that remote pulmonary injury is significantly decreased by concomitant PentaLyte- mediated reduction of hepatoenteric reperfusion injury and XO release.

Original languageEnglish (US)
Pages (from-to)1982-1990
Number of pages9
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume157
Issue number6 I
StatePublished - 1998
Externally publishedYes

Fingerprint

Lung Injury
Reperfusion
Reperfusion Injury
Hydroxyethyl Starch Derivatives
Resuscitation
Xanthine Oxidase
Bronchoalveolar Lavage Fluid
Enzymes
Aspartate Aminotransferases
L-Lactate Dehydrogenase
Oxidants
Intestines
PentaLyte
Stomach
Ischemia
Rabbits
Ringer's lactate
Ringer's solution
Liver
Wounds and Injuries

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

PentaLyte decreases lung injury after aortic occlusion-reperfusion. / Axon, R. N.; Baird, M. S.; Lang, J. D.; Brix, A. E.; Nielsen, Vance G.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 157, No. 6 I, 1998, p. 1982-1990.

Research output: Contribution to journalArticle

Axon, R. N. ; Baird, M. S. ; Lang, J. D. ; Brix, A. E. ; Nielsen, Vance G. / PentaLyte decreases lung injury after aortic occlusion-reperfusion. In: American Journal of Respiratory and Critical Care Medicine. 1998 ; Vol. 157, No. 6 I. pp. 1982-1990.
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