Peptide map comparisons of epidermal and spleen H-2 molecules

John G. Frelinger, Jeffrey A. Frelinger, Leroy Hood

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Peptide map comparisons of molecules encoded in the mouse H-2 complex isolated from epidermal cell preparations have been carried out. We previously showed that the Ia molecules from both the I-A and I-E subregions are synthesized by nonlymphoid bone-marrow-derived cells, probably Langerhans cells. The K and D or transplantation molecules are synthesized by both "true" epidermal cells and nonlymphoid bone-marrow-derived cells. The tryptic maps generated by separating tryptic peptides by high pressure liquid chromatography (HPLC) of epidermal H-2 molecules are identical to their spleen-cell counterparts. The biological significance of this finding is discussed.

Original languageEnglish (US)
Pages (from-to)569-577
Number of pages9
JournalImmunogenetics
Volume12
Issue number1
DOIs
StatePublished - Dec 1981
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Genetics

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