Peptidomimetics, a synthetic tool of drug discovery

Research output: Contribution to journalReview article

315 Scopus citations


The demand for modified peptides with improved stability profiles and pharmacokinetic properties is driving extensive research effort in this field. Many structural modifications of peptides guided by rational design and molecular modeling have been established to develop novel synthetic approaches. Recent advances in the synthesis of conformationally restricted building blocks and peptide bond isosteres are discussed.

Original languageEnglish (US)
Pages (from-to)292-296
Number of pages5
JournalCurrent Opinion in Chemical Biology
Issue number3
StatePublished - Jun 1 2008


ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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