Performance of an Ideal Attenuation and Scatter Correction Strategy for a Next-Generation SPECT System Dedicated to Quantitative Clinical Brain Imaging

Benjamin Auer, Jan De Beenhouwer, Navid Zeraatkar, Philip H. Kuo, Lars R. Furenlid, Michael A. King

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A next-generation, adaptive, multi-pinhole system, AdaptiSPECT-C, dedicated to SPECT brain imaging is currently under development in our research team. Attenuation and scatter correction have proven to be critical to enhance image quality and quantification for brain imaging. The motivation for this investigation was to determine the enhancement in image quality by adding scatter correction strategy in addition to attenuation correction for brain imaging with AdaptiSPECT-C. An ideal scatter correction strategy was investigated in this GATE simulation study using a brain perfusion phantom and compared to the reference case for which an air attenuation medium was considered. We demonstrated that the use of the attenuation and the ideal scatter correction strategy significantly enhanced the imaging performance of AdaptiSPECT-C in case of clinical 123I brain perfusion imaging. In addition, our study concluded that the use of an attenuation correction without compensating for scatter strongly degrades the contrast of the reconstruction, despite a quantitative improvement compared to the case for which no correction was used.

Original languageEnglish (US)
Title of host publication2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781728141640
DOIs
StatePublished - Oct 2019
Event2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019 - Manchester, United Kingdom
Duration: Oct 26 2019Nov 2 2019

Publication series

Name2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019

Conference

Conference2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019
CountryUnited Kingdom
CityManchester
Period10/26/1911/2/19

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Keywords

  • I SPECT imaging
  • next-generation clinical system
  • scatter and attenuation correction

ASJC Scopus subject areas

  • Signal Processing
  • Radiology Nuclear Medicine and imaging
  • Nuclear and High Energy Physics

Cite this

Auer, B., De Beenhouwer, J., Zeraatkar, N., Kuo, P. H., Furenlid, L. R., & King, M. A. (2019). Performance of an Ideal Attenuation and Scatter Correction Strategy for a Next-Generation SPECT System Dedicated to Quantitative Clinical Brain Imaging. In 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019 [9059942] (2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSS/MIC42101.2019.9059942