Periparturient changes in secretion and mammary uptake of insulin and in concentrations of insulin and insulin-like growth factors in milk of dairy cows.

P. V. Malven, H. H. Head, Robert J Collier, F. C. Buonomo

Research output: Contribution to journalArticle

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Abstract

Mammary uptake of insulin from blood was quantified near parturition in nine dairy cows, some of which were milked prepartum to induce prepartum lactogenesis. Milk samples were immunoassayed for concentrations of insulin, insulin-like growth factor I, and insulin-like growth factor II. Cows milked prepartum, but in which prepartum lactogenesis did not occur (denoted as unsuccessful group), had higher arterial concentrations and greater mammary uptake of insulin during several days immediately preceding parturition than did those with prepartum lactogenesis. Although mammary uptake of insulin was measurable before parturition, estimated uptake on postpartum d 4 through 6 was negligible. Colostrum and milk contained very substantial quantities of insulin, insulin-like growth factor I, and insulin-like growth factor II. Cows in which prepartum lactogenesis was induced (denoted as successful group) had lower concentrations of both forms of insulin-like growth factor in prepartum samples of milk. Cows of the successful group also had a decreasing prepartum profile of milk insulin, but the unsuccessful group had an increasing trend until parturition. Milk concentrations of insulin and both forms of insulin-like growth factor declined rapidly after parturition and completion of lactogenesis.

Original languageEnglish (US)
Pages (from-to)2254-2265
Number of pages12
JournalJournal of Dairy Science
Volume70
Issue number11
StatePublished - Nov 1987
Externally publishedYes

Fingerprint

somatomedins
Somatomedins
milk synthesis
breasts
Milk
Breast
insulin
dairy cows
secretion
Insulin
uptake mechanisms
Parturition
parturition
milk
insulin-like growth factor II
Insulin-Like Growth Factor II
insulin-like growth factor I
Insulin-Like Growth Factor I
cows
Colostrum

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Food Science
  • veterinary(all)

Cite this

Periparturient changes in secretion and mammary uptake of insulin and in concentrations of insulin and insulin-like growth factors in milk of dairy cows. / Malven, P. V.; Head, H. H.; Collier, Robert J; Buonomo, F. C.

In: Journal of Dairy Science, Vol. 70, No. 11, 11.1987, p. 2254-2265.

Research output: Contribution to journalArticle

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