Peripheral blood non-canonical small non-coding RNAs as novel biomarkers in lung cancer

Wanjun Gu, Junchao Shi, Hui Liu, Xudong Zhang, Jin J. Zhou, Musheng Li, Dandan Zhou, Rui Li, Jingzhu Lv, Guoxia Wen, Shanshan Zhu, Ting Qi, Wei Li, Xiaojing Wang, Zhaohua Wang, Hua Zhu, Changcheng Zhou, Kenneth S. Knox, Ting Wang, Qi ChenZhongqing Qian, Tong Zhou

Research output: Contribution to journalLetterpeer-review

7 Scopus citations

Abstract

One unmet challenge in lung cancer diagnosis is to accurately differentiate lung cancer from other lung diseases with similar clinical symptoms and radiological features, such as pulmonary tuberculosis (TB). To identify reliable biomarkers for lung cancer screening, we leverage the recently discovered non-canonical small non-coding RNAs (i.e., tRNA-derived small RNAs [tsRNAs], rRNA-derived small RNAs [rsRNAs], and YRNA-derived small RNAs [ysRNAs]) in human peripheral blood mononuclear cells and develop a molecular signature composed of distinct ts/rs/ysRNAs (TRY-RNA). Our TRY-RNA signature precisely discriminates between control, lung cancer, and pulmonary TB subjects in both the discovery and validation cohorts and outperforms microRNA-based biomarkers, which bears the diagnostic potential for lung cancer screening.

Original languageEnglish (US)
Article number159
JournalMolecular Cancer
Volume19
Issue number1
DOIs
StatePublished - Dec 2020

Keywords

  • Lung cancer
  • Tuberculosis
  • rsRNA
  • tsRNA
  • ysRNA

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Cancer Research

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