Peripheral circulatory control of cardiac output in diabetic rats

S. E. Litwin, T. E. Raya, S. Daugherty, Steven Goldman

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Diabetes is believed to be associated with impaired systolic and diastolic function of the heart; however, some investigators have found that diabetic rats have increased cardiac output. We investigated changes in the peripheral circulation that could account for an increased cardiac output in diabetic rats (n = 30), 4 wk after a single tail vein injection of streptozotocin (60 mg/kg), and age-matched control rats (n = 31). Compared with controls, diabetic rats exhibited decreased (P < 0.05) mean arterial pressure, characteristic aortic impedance, and total peripheral resistance; however, cardiac index and stroke volume index were increased. Aortic compliance, mean circulatory filling pressure, central venous pressure, pressure gradient for venous return, and venous compliance were unchanged in the diabetic rats compared with control. Baseline left ventricular end-diastolic pressure and end-diastolic volume were increased in the diabetic rats. Following a volume load of 30 ml/kg, cardiac index and stroke volume index increased less in the diabetic than in the control rats (35 vs. 102% and 69 vs. 105%, respectively). Thus, even with impaired systolic function, cardiac output is increased or maintained in diabetic rats because of the combination of decreased afterload and maintenance of preload.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume261
Issue number3 30-3
StatePublished - 1991
Externally publishedYes

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Cardiac Output
Cardiac Volume
Stroke Volume
Compliance
Central Venous Pressure
Venous Pressure
Streptozocin
Electric Impedance
Vascular Resistance
Tail
Veins
Arterial Pressure
Maintenance
Research Personnel
Blood Pressure
Pressure
Injections

Keywords

  • Aortic impedance
  • Blood volume
  • Venous compliance

ASJC Scopus subject areas

  • Physiology

Cite this

Peripheral circulatory control of cardiac output in diabetic rats. / Litwin, S. E.; Raya, T. E.; Daugherty, S.; Goldman, Steven.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 261, No. 3 30-3, 1991.

Research output: Contribution to journalArticle

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