Peripheral Delivery of a ROCK Inhibitor Improves Learning and Working Memory

Matthew J. Huentelman, Dietrich A. Stephan, Joshua Talboom, Jason J. Corneveaux, David M. Reiman, Jill D. Gerber, Carol A. Barnes, Gene E. Alexander, Eric M. Reiman, Heather A. Bimonte-Nelson

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Previously, utilizing a series of genome-wide association, brain imaging, and gene expression studies we implicated the KIBRA gene and the RhoA/ROCK pathway in hippocampal-mediated human memory. Here we show that peripheral administration of the ROCK inhibitor hydroxyfasudil improves spatial learning and working memory in the rodent model. This study supports the action of ROCK on learning and memory, suggests the potential value of ROCK inhibition for the promotion of cognition in humans, and highlights the powerful potential of unbiased genome-wide association studies to inform potential novel uses for existing pharmaceuticals.

Original languageEnglish (US)
Pages (from-to)218-223
Number of pages6
JournalBehavioral Neuroscience
Volume123
Issue number1
DOIs
StatePublished - Feb 2009

Keywords

  • ROCK
  • aging
  • fasudil
  • learning
  • memory

ASJC Scopus subject areas

  • Behavioral Neuroscience

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    Huentelman, M. J., Stephan, D. A., Talboom, J., Corneveaux, J. J., Reiman, D. M., Gerber, J. D., Barnes, C. A., Alexander, G. E., Reiman, E. M., & Bimonte-Nelson, H. A. (2009). Peripheral Delivery of a ROCK Inhibitor Improves Learning and Working Memory. Behavioral Neuroscience, 123(1), 218-223. https://doi.org/10.1037/a0014260