Peritoneal clearance and total body elimination of vancomycin during chronic intermittent peritoneal dialysis

J. C. Ayus, J. F. Eneas, T. G. Tong, N. L. Benowitz, P. Y. Schoenfeld, K. L. Hadley, C. E. Becker, M. H. Humphreys

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Vancomycin is a useful antimicrobial agent in patients undergoing chronic hemodialysis treatment; its efficacy in chronic peritoneal dialysis (CPD) has not been established. Serum (V(S)) and peritoneal fluid (V(PF)) vancomycin concentrations were measured in two CPD patients with staphylococcal peritonitis. Half-life of V(S) agreed with the half-life of V(PF) in each patient and the V(S)/V(PF) ratio was 1.27 in both patients. Distribution volumes were 37.2 and 58.7 l, values approximating total body water in these patients. V(S) and V(PF) persisted in the therapeutic range (>5 μg/ml) for more than 16 days. In one patient, mean peritoneal clearance was 9.8 ml/min and overall drug clearance averaged 2.3 ml/min; in the other patient, overall clearance was 2.1 ml/min. These results indicate that therapeutic vancomycin levels can be maintained for more than 16 days with a single 1 g intravenous dose in patients receiving intermittent CPD, as is the case for hemodialysis patients. Because of this, parenteral vancomycin is useful in the treatment of staphylococcal peritonitis in CPD patients.

Original languageEnglish (US)
Pages (from-to)129-132
Number of pages4
JournalClinical Nephrology
Volume11
Issue number3
StatePublished - Dec 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology

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    Ayus, J. C., Eneas, J. F., Tong, T. G., Benowitz, N. L., Schoenfeld, P. Y., Hadley, K. L., Becker, C. E., & Humphreys, M. H. (1979). Peritoneal clearance and total body elimination of vancomycin during chronic intermittent peritoneal dialysis. Clinical Nephrology, 11(3), 129-132.