Peroxidase-ROS interactions\

William M Schaffer, T. V. Bronnikova

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Reactive oxygen species (ROS), such as hydrogen peroxide and superoxide anion radical, have long been recognized as harmful by-products of oxidative metabolism. Under normal physiologic conditions, hydrogen peroxide and superoxide are detoxified by antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx). Heme peroxidases (eosinophil peroxidase (EPO), lactoperoxidase (LPO), myeloperoxidase (MPO), etc.) also consume ROS, but unlike scavenging enzymes, are sources of these species as well. In the present paper, we study a well-tested model of the peroxidase-oxidase (PO) reaction based on horseradish peroxidase (HRP) chemistry with regard to the production and consumption of hydrogen peroxide and superoxide. Our principal results are these: 1. PO reactions can transduce continuing infusions of hydrogen peroxide and superoxide into bounded dynamics. 2. Absent exogenous ROS input, and under conditions that retard hydrogen donor autoxidation, PO reactions can manifest low frequency bursting whereby pulses of ROS are produced at clinically significant intervals. The relevance of these results to the functional significance of fluctuating ROS concentrations in vivo, to neurodevelopmental and neurodegenerative disease and to episodic and progressive symptomatology is discussed.

Original languageEnglish (US)
Pages (from-to)413-430
Number of pages18
JournalNonlinear Dynamics
Volume68
Issue number3
DOIs
StatePublished - May 2012

Fingerprint

Reactive Oxygen Species
Peroxidase
Hydrogen peroxide
Hydrogen Peroxide
Oxygen
Interaction
Enzymes
Neurodegenerative diseases
Scavenging
Antioxidants
Metabolism
Superoxide Dismutase
Catalase
Byproducts
Glutathione
Bursting
Negative ions
Chemistry
Hydrogen
Low Frequency

Keywords

  • Bistability
  • Bursting
  • Episodic symptomatology
  • Hydrogen peroxide
  • Hydrogen peroxide blow-up
  • Hysteresis
  • Inflammation
  • Multiple sclerosis
  • Neurodegenerative disease
  • Neurodevelopmental disease
  • Oxidative stress
  • Peroxidase-oxidase reaction
  • Reactive oxygen species
  • ROS
  • Superoxide

ASJC Scopus subject areas

  • Applied Mathematics
  • Mechanical Engineering
  • Aerospace Engineering
  • Ocean Engineering
  • Electrical and Electronic Engineering
  • Control and Systems Engineering

Cite this

Peroxidase-ROS interactions\. / Schaffer, William M; Bronnikova, T. V.

In: Nonlinear Dynamics, Vol. 68, No. 3, 05.2012, p. 413-430.

Research output: Contribution to journalArticle

Schaffer, William M ; Bronnikova, T. V. / Peroxidase-ROS interactions\. In: Nonlinear Dynamics. 2012 ; Vol. 68, No. 3. pp. 413-430.
@article{bceac5d1bb01483da9ac35956ff05473,
title = "Peroxidase-ROS interactions\",
abstract = "Reactive oxygen species (ROS), such as hydrogen peroxide and superoxide anion radical, have long been recognized as harmful by-products of oxidative metabolism. Under normal physiologic conditions, hydrogen peroxide and superoxide are detoxified by antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx). Heme peroxidases (eosinophil peroxidase (EPO), lactoperoxidase (LPO), myeloperoxidase (MPO), etc.) also consume ROS, but unlike scavenging enzymes, are sources of these species as well. In the present paper, we study a well-tested model of the peroxidase-oxidase (PO) reaction based on horseradish peroxidase (HRP) chemistry with regard to the production and consumption of hydrogen peroxide and superoxide. Our principal results are these: 1. PO reactions can transduce continuing infusions of hydrogen peroxide and superoxide into bounded dynamics. 2. Absent exogenous ROS input, and under conditions that retard hydrogen donor autoxidation, PO reactions can manifest low frequency bursting whereby pulses of ROS are produced at clinically significant intervals. The relevance of these results to the functional significance of fluctuating ROS concentrations in vivo, to neurodevelopmental and neurodegenerative disease and to episodic and progressive symptomatology is discussed.",
keywords = "Bistability, Bursting, Episodic symptomatology, Hydrogen peroxide, Hydrogen peroxide blow-up, Hysteresis, Inflammation, Multiple sclerosis, Neurodegenerative disease, Neurodevelopmental disease, Oxidative stress, Peroxidase-oxidase reaction, Reactive oxygen species, ROS, Superoxide",
author = "Schaffer, {William M} and Bronnikova, {T. V.}",
year = "2012",
month = "5",
doi = "10.1007/s11071-011-0314-x",
language = "English (US)",
volume = "68",
pages = "413--430",
journal = "Nonlinear Dynamics",
issn = "0924-090X",
publisher = "Springer Netherlands",
number = "3",

}

TY - JOUR

T1 - Peroxidase-ROS interactions\

AU - Schaffer, William M

AU - Bronnikova, T. V.

PY - 2012/5

Y1 - 2012/5

N2 - Reactive oxygen species (ROS), such as hydrogen peroxide and superoxide anion radical, have long been recognized as harmful by-products of oxidative metabolism. Under normal physiologic conditions, hydrogen peroxide and superoxide are detoxified by antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx). Heme peroxidases (eosinophil peroxidase (EPO), lactoperoxidase (LPO), myeloperoxidase (MPO), etc.) also consume ROS, but unlike scavenging enzymes, are sources of these species as well. In the present paper, we study a well-tested model of the peroxidase-oxidase (PO) reaction based on horseradish peroxidase (HRP) chemistry with regard to the production and consumption of hydrogen peroxide and superoxide. Our principal results are these: 1. PO reactions can transduce continuing infusions of hydrogen peroxide and superoxide into bounded dynamics. 2. Absent exogenous ROS input, and under conditions that retard hydrogen donor autoxidation, PO reactions can manifest low frequency bursting whereby pulses of ROS are produced at clinically significant intervals. The relevance of these results to the functional significance of fluctuating ROS concentrations in vivo, to neurodevelopmental and neurodegenerative disease and to episodic and progressive symptomatology is discussed.

AB - Reactive oxygen species (ROS), such as hydrogen peroxide and superoxide anion radical, have long been recognized as harmful by-products of oxidative metabolism. Under normal physiologic conditions, hydrogen peroxide and superoxide are detoxified by antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx). Heme peroxidases (eosinophil peroxidase (EPO), lactoperoxidase (LPO), myeloperoxidase (MPO), etc.) also consume ROS, but unlike scavenging enzymes, are sources of these species as well. In the present paper, we study a well-tested model of the peroxidase-oxidase (PO) reaction based on horseradish peroxidase (HRP) chemistry with regard to the production and consumption of hydrogen peroxide and superoxide. Our principal results are these: 1. PO reactions can transduce continuing infusions of hydrogen peroxide and superoxide into bounded dynamics. 2. Absent exogenous ROS input, and under conditions that retard hydrogen donor autoxidation, PO reactions can manifest low frequency bursting whereby pulses of ROS are produced at clinically significant intervals. The relevance of these results to the functional significance of fluctuating ROS concentrations in vivo, to neurodevelopmental and neurodegenerative disease and to episodic and progressive symptomatology is discussed.

KW - Bistability

KW - Bursting

KW - Episodic symptomatology

KW - Hydrogen peroxide

KW - Hydrogen peroxide blow-up

KW - Hysteresis

KW - Inflammation

KW - Multiple sclerosis

KW - Neurodegenerative disease

KW - Neurodevelopmental disease

KW - Oxidative stress

KW - Peroxidase-oxidase reaction

KW - Reactive oxygen species

KW - ROS

KW - Superoxide

UR - http://www.scopus.com/inward/record.url?scp=84862998372&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862998372&partnerID=8YFLogxK

U2 - 10.1007/s11071-011-0314-x

DO - 10.1007/s11071-011-0314-x

M3 - Article

AN - SCOPUS:84862998372

VL - 68

SP - 413

EP - 430

JO - Nonlinear Dynamics

JF - Nonlinear Dynamics

SN - 0924-090X

IS - 3

ER -