Perspectives on the mechanism of ATP hydrolysis by nitrogenase

Stephan O. Krause, William G. Gutheil, Anton M. Simeonov, Terry O Matsunaga, Margaret J. Stauber, George L. Kenyon, Charles E. Mckenna

Research output: Contribution to journalArticle

Abstract

The chemical mechanism of ATP hydrolysis by nitrogenase is discussed in terms of results from isotopic exchange studies using [18O4]-Pi, b,g-[18O]-ATP, and g-[18O4]-ATP as probes of reversibility (ATP = ADP + Pi) and of the freedom of rotation around the O-Pb bond in enzyme-bound ADP.

Original languageEnglish (US)
Pages (from-to)513-516
Number of pages4
JournalPhosphorus, Sulfur and Silicon and Related Elements
Volume144-146
StatePublished - 1999
Externally publishedYes

Fingerprint

Nitrogenase
Hydrolysis
Adenosine Triphosphate
Adenosine Diphosphate
Enzymes

Keywords

  • P NMR
  • [O]-phosphate
  • ATP hydrolysis
  • g-[O]-ATP
  • HRMS
  • Nitrogenase
  • PIX

ASJC Scopus subject areas

  • Inorganic Chemistry

Cite this

Krause, S. O., Gutheil, W. G., Simeonov, A. M., Matsunaga, T. O., Stauber, M. J., Kenyon, G. L., & Mckenna, C. E. (1999). Perspectives on the mechanism of ATP hydrolysis by nitrogenase. Phosphorus, Sulfur and Silicon and Related Elements, 144-146, 513-516.

Perspectives on the mechanism of ATP hydrolysis by nitrogenase. / Krause, Stephan O.; Gutheil, William G.; Simeonov, Anton M.; Matsunaga, Terry O; Stauber, Margaret J.; Kenyon, George L.; Mckenna, Charles E.

In: Phosphorus, Sulfur and Silicon and Related Elements, Vol. 144-146, 1999, p. 513-516.

Research output: Contribution to journalArticle

Krause, SO, Gutheil, WG, Simeonov, AM, Matsunaga, TO, Stauber, MJ, Kenyon, GL & Mckenna, CE 1999, 'Perspectives on the mechanism of ATP hydrolysis by nitrogenase', Phosphorus, Sulfur and Silicon and Related Elements, vol. 144-146, pp. 513-516.
Krause SO, Gutheil WG, Simeonov AM, Matsunaga TO, Stauber MJ, Kenyon GL et al. Perspectives on the mechanism of ATP hydrolysis by nitrogenase. Phosphorus, Sulfur and Silicon and Related Elements. 1999;144-146:513-516.
Krause, Stephan O. ; Gutheil, William G. ; Simeonov, Anton M. ; Matsunaga, Terry O ; Stauber, Margaret J. ; Kenyon, George L. ; Mckenna, Charles E. / Perspectives on the mechanism of ATP hydrolysis by nitrogenase. In: Phosphorus, Sulfur and Silicon and Related Elements. 1999 ; Vol. 144-146. pp. 513-516.
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