Persufflation (gaseous oxygen perfusion) as a method of heart preservation

Thomas M. Suszynski, Michael D. Rizzari, William E. Scott, Peter M. Eckman, James D. Fonger, Ranjit John, Nicolas Chronos, Linda A. Tempelman, David E R Sutherland, Klearchos K Papas

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Persufflation (PSF; gaseous oxygen perfusion) is an organ preservation technique with a potential for use in donor heart preservation. Improved heart preservation with PSF may improve outcomes by maintaining cardiac tissue quality in the setting of longer cold ischemia times and possibly increasing the number of donor hearts available for allotransplant. Published data suggests that PSF is able to extend the cold storage times for porcine hearts up to 14 hours without compromising viability and function, and has been shown to resuscitate porcine hearts following donation after cardiac death. This review summarizes key published work on heart PSF, including prospective implications and future directions for PSF in heart transplantation. We emphasize the potential impact of extending preservation times and expanding donor selection criteria in heart allotransplant. Additionally, the key issues that need to be addressed before PSF were to become a widely utilized preservation strategy prior to clinical heart transplantation are summarized and discussed.

Original languageEnglish (US)
Article number105
JournalJournal of Cardiothoracic Surgery
Volume8
Issue number1
DOIs
StatePublished - Apr 22 2013

Fingerprint

Perfusion
Oxygen
Heart Transplantation
Swine
Organ Preservation
Cold Ischemia
Donor Selection
Patient Selection

Keywords

  • Heart transplantation
  • Ischemia
  • Organ preservation
  • Perfusion

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Suszynski, T. M., Rizzari, M. D., Scott, W. E., Eckman, P. M., Fonger, J. D., John, R., ... Papas, K. K. (2013). Persufflation (gaseous oxygen perfusion) as a method of heart preservation. Journal of Cardiothoracic Surgery, 8(1), [105]. https://doi.org/10.1186/1749-8090-8-105

Persufflation (gaseous oxygen perfusion) as a method of heart preservation. / Suszynski, Thomas M.; Rizzari, Michael D.; Scott, William E.; Eckman, Peter M.; Fonger, James D.; John, Ranjit; Chronos, Nicolas; Tempelman, Linda A.; Sutherland, David E R; Papas, Klearchos K.

In: Journal of Cardiothoracic Surgery, Vol. 8, No. 1, 105, 22.04.2013.

Research output: Contribution to journalArticle

Suszynski, TM, Rizzari, MD, Scott, WE, Eckman, PM, Fonger, JD, John, R, Chronos, N, Tempelman, LA, Sutherland, DER & Papas, KK 2013, 'Persufflation (gaseous oxygen perfusion) as a method of heart preservation', Journal of Cardiothoracic Surgery, vol. 8, no. 1, 105. https://doi.org/10.1186/1749-8090-8-105
Suszynski TM, Rizzari MD, Scott WE, Eckman PM, Fonger JD, John R et al. Persufflation (gaseous oxygen perfusion) as a method of heart preservation. Journal of Cardiothoracic Surgery. 2013 Apr 22;8(1). 105. https://doi.org/10.1186/1749-8090-8-105
Suszynski, Thomas M. ; Rizzari, Michael D. ; Scott, William E. ; Eckman, Peter M. ; Fonger, James D. ; John, Ranjit ; Chronos, Nicolas ; Tempelman, Linda A. ; Sutherland, David E R ; Papas, Klearchos K. / Persufflation (gaseous oxygen perfusion) as a method of heart preservation. In: Journal of Cardiothoracic Surgery. 2013 ; Vol. 8, No. 1.
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