Pertussis: The disease and new diagnostic methods

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

While progress has been made in the development of rapid diagnostic tests for B. pertussis, presently culture and the DFA test are still the methods of choice for confirmatory diagnosis of pertussis. Serologic ELISAs for detection of anti-pertussis antibody in sera or nasal secretions hold promise as important tools in epidemiologic studies of pertussis but not as rapid diagnostic tests. The most promising diagnostic methods for the future appear to be the use of DNA probes and methods to directly detect B. pertussis antigens in nasopharyngeal specimens. This includes use of specific monoclonal antibodies or assaying for the AC enzyme of B. pertussis. Further extensive laboratory studies, research, and field trial evaluations will need to be done to determine the sensitivity, specificity, and value of these methods as new rapid diagnostic tests for the diagnosis of pertussis.

Original languageEnglish (US)
Pages (from-to)365-376
Number of pages12
JournalClinical Microbiology Reviews
Volume1
Issue number4
StatePublished - 1988

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Whooping Cough
Routine Diagnostic Tests
DNA Probes
Nose
Epidemiologic Studies
Anti-Idiotypic Antibodies
Enzyme-Linked Immunosorbent Assay
Monoclonal Antibodies
Antigens
Sensitivity and Specificity
Enzymes
Serum
Research

ASJC Scopus subject areas

  • Microbiology

Cite this

Pertussis : The disease and new diagnostic methods. / Friedman, Richard L.

In: Clinical Microbiology Reviews, Vol. 1, No. 4, 1988, p. 365-376.

Research output: Contribution to journalArticle

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