Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study

Leslie K Dennis, Charles F. Lynch, Dale P. Sandler, Michael C R Alavanja

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Background: Melanoma rates continue to increase; however, few risk factors other than sun sensitivity and ultraviolet radiation (including sun exposure) have been identified. Although studies of farmers have shown an excess risk of melanoma and other skin cancers, it is unclear how much of this is related to sun exposure compared with other agricultural exposures. Methods: We examined dose-response relationships for 50 agricultural pesticides and cutaneous melanoma incidence in the Agricultural Health Study cohort of licensed pesticide applicators, along with ever use of older pesticides that contain arsenic. Logistic regression was used to examine odds ratios (ORs) and 95% confidence intervals (CIs) associated with pesticide exposure adjusted for age, sex, and other potential confounders. Results: We found significant associations between cutaneous melanoma and maneb/mancozeb (≥ 63 exposure days: OR = 2.4; 95% CI, 1.2-4.9; trend p = 0.006), parathion (≥ 56 exposure days: OR = 2.4; 95% CI, 1.3-4.4; trend p = 0.003), and carbaryl (≥ 56 exposure days: OR = 1.7; 95% CI, 1.1-2.5; trend p = 0.013). Other associations with benomyl and ever use of arsenical pesticides were also suggested. conclusions: Most previous melanoma literature has focused on host factors and sun exposure. Our research shows an association between several pesticides and melanoma, providing support for the hypotheses that agricultural chemicals may be another important source of melanoma risk.

Original languageEnglish (US)
Pages (from-to)812-817
Number of pages6
JournalEnvironmental Health Perspectives
Volume118
Issue number6
DOIs
StatePublished - Jun 2010
Externally publishedYes

Fingerprint

Pesticides
Melanoma
Skin
Solar System
Odds Ratio
Confidence Intervals
Maneb
Benomyl
Carbaryl
Parathion
Agrochemicals
Arsenicals
Radiation Tolerance
Arsenic
Skin Neoplasms
Cohort Studies
Logistic Models
Incidence
Health
Research

Keywords

  • Arsenic
  • Farmers
  • Melanoma
  • Pesticides

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Medicine(all)

Cite this

Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study. / Dennis, Leslie K; Lynch, Charles F.; Sandler, Dale P.; Alavanja, Michael C R.

In: Environmental Health Perspectives, Vol. 118, No. 6, 06.2010, p. 812-817.

Research output: Contribution to journalArticle

Dennis, Leslie K ; Lynch, Charles F. ; Sandler, Dale P. ; Alavanja, Michael C R. / Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study. In: Environmental Health Perspectives. 2010 ; Vol. 118, No. 6. pp. 812-817.
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