Pesticides and hypospadias

A meta-analysis

Carissa M. Rocheleau, Paul A. Romitti, Leslie K Dennis

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Objective: To use meta-analytic techniques to synthesize the findings of the current body of published literature regarding the risk of hypospadias resulting from parental exposure to pesticides. Materials and methods: A search of Pub Med for original research published in English from January 1966 through March 2008 identified 552 studies, 90 of which were reviewed in detail. Nine studies met all study inclusion criteria. Two reviewers independently abstracted data from each included study. Any disagreements were resolved by consensus. Pooled risk ratios (PRRs) and confidence intervals (CIs) were calculated using both random and fixed effects models, along with statistical tests of homogeneity. Results: Elevated but marginally significant risks of hypospadias were associated with maternal occupational exposure (PRR of 1.36, CI = 1.04-1.77), and paternal occupational exposure (PRR of 1.19, CI = 1.00-1.41). Subgroup analyses provided insights into needed designs for future studies. Notably, exposure assessment using a job-exposure matrix resulted in slightly higher estimated risk than agricultural occupation in fathers; but this effect was reversed in mothers, suggesting the importance of indirect and residential pesticide exposures in this group. Conclusions: Despite potential exposure misclassification, which would tend to diminish observed associations, the previous literature indicates a modestly increased risk of hypospadias associated with pesticide exposure.

Original languageEnglish (US)
Pages (from-to)17-24
Number of pages8
JournalJournal of Pediatric Urology
Volume5
Issue number1
DOIs
StatePublished - Feb 2009
Externally publishedYes

Fingerprint

Hypospadias
Pesticides
Meta-Analysis
Odds Ratio
Confidence Intervals
Occupational Exposure
Paternal Exposure
Maternal Exposure
Occupations
Fathers
Consensus
Mothers
Research

Keywords

  • Congenital abnormalities
  • Hypospadias
  • Meta-analysis
  • Pesticides
  • Pregnancy

ASJC Scopus subject areas

  • Urology
  • Pediatrics, Perinatology, and Child Health

Cite this

Pesticides and hypospadias : A meta-analysis. / Rocheleau, Carissa M.; Romitti, Paul A.; Dennis, Leslie K.

In: Journal of Pediatric Urology, Vol. 5, No. 1, 02.2009, p. 17-24.

Research output: Contribution to journalArticle

Rocheleau, Carissa M. ; Romitti, Paul A. ; Dennis, Leslie K. / Pesticides and hypospadias : A meta-analysis. In: Journal of Pediatric Urology. 2009 ; Vol. 5, No. 1. pp. 17-24.
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