PET reveals occipitotemporal pathway activation during elementary form perception in humans

Lori L. Beason-Held, Keith P. Purpura, John W. Van Meter, Nina P. Azari, David J. Mangot, Lance M. Optican, Marc J. Mentis, Gene E. Alexander, Cheryl L. Grady, Barry Horwitz, Stanley I. Rapoport, Mark B. Schapiro

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

To define brain regions involved in feature extraction or elementary form perception, regional cerebral blood flow (rCBF) was measured using positron emission tomography (PET) in subjects viewing two classes of achromatic textures. Textures composed of local features (e.g. extended contours and rectangular blocks) produced activation or increased rCBF along the occipitotemporal pathway relative to textures with the same mean luminance, contrast, and spatial-frequency content but lacking organized form elements or local features. Significant activation was observed in striate, extrastriate, lingual, and fusiform cortices as well as the hippocampus and brain stem. On a scan-by-scan basis, increases in rCBF shifted from the occipitotemporal visual cortices to medial temporal (hippocampus) and frontal lobes with increased exposure to only those textures containing local features. These results suggest that local feature extraction occurs throughout the occipitotemporal (ventral) pathway during extended exposure to visually salient stimuli, and may indicate the presence of similar receptive-field mechanisms in both occipital and temporal visual areas of the human brain.

Original languageEnglish (US)
Pages (from-to)503-510
Number of pages8
JournalVisual neuroscience
Volume15
Issue number3
DOIs
StatePublished - May 1 1998
Externally publishedYes

Keywords

  • Extrastriate
  • Frontal lobe
  • Hippocampus
  • Positron emission tomography
  • Striate
  • Visual

ASJC Scopus subject areas

  • Physiology
  • Sensory Systems

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    Beason-Held, L. L., Purpura, K. P., Van Meter, J. W., Azari, N. P., Mangot, D. J., Optican, L. M., Mentis, M. J., Alexander, G. E., Grady, C. L., Horwitz, B., Rapoport, S. I., & Schapiro, M. B. (1998). PET reveals occipitotemporal pathway activation during elementary form perception in humans. Visual neuroscience, 15(3), 503-510. https://doi.org/10.1017/S0952523898153117