Phage Application for the Protection from Acute Hepatopancreatic Necrosis Disease (AHPND) in Penaeus vannamei

Jin Woo Jun, Jee Eun Han, Sib Sankar Giri, Kathy F.J. Tang, Xiaohui Zhou, Luis Fernando Aranguren, Hyoun Joong Kim, Saekil Yun, Cheng Chi, Sang Guen Kim, Se Chang Park

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Acute hepatopancreatic necrosis disease (AHPND) caused by Vibrio parahaemolyticus has been one of the most problematic diseases in marine shrimp aquaculture throughout Southeast Asia and Latin America. To evaluate the effectiveness of a bacteriophage (phage) treatment for AHPND, a series of bioassays were carried out in a marine shrimp (Penaeus vannamei) model using an AHPND-V. parahaemolyticus strain that is highly pathogenic to shrimp. We monitored the mortality and histopathological changes during phage treatment. Shrimps treated with phage prophylaxis and phage therapy displayed significant protection from AHPND and survived a lethal bacterial challenge.

Original languageEnglish (US)
Pages (from-to)114-117
Number of pages4
JournalIndian Journal of Microbiology
Volume58
Issue number1
DOIs
StatePublished - Mar 1 2018

Keywords

  • Acute hepatopancreatic necrosis disease (AHPND)
  • Phage prophylaxis
  • Phage therapy
  • Vibrio parahaemolyticus

ASJC Scopus subject areas

  • Microbiology

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