Phantom study of tear film dynamics with optical coherence tomography and maximum-likelihood estimation

Jinxin Huang, Kye Sung Lee, Eric W Clarkson, Matthew A Kupinski, Kara L. Maki, David S. Ross, James V. Aquavella, Jannick P. Rolland

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In this Letter, we implement a maximum-likelihood estimator to interpret optical coherence tomography (OCT) data for the first time, based on Fourier-domain OCT and a two-interface tear film model. We use the root mean square error as a figure of merit to quantify the system performance of estimating the tear film thickness. With the methodology of task-based assessment, we study the trade-off between system imaging speed (temporal resolution of the dynamics) and the precision of the estimation. Finally, the estimator is validated with a digital tear-film dynamics phantom.

Original languageEnglish (US)
Pages (from-to)1721-1723
Number of pages3
JournalOptics Letters
Volume38
Issue number10
DOIs
StatePublished - May 15 2013

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Optical Coherence Tomography
Tears
estimators
tomography
root-mean-square errors
temporal resolution
figure of merit
film thickness
estimating
methodology

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Medicine(all)

Cite this

Phantom study of tear film dynamics with optical coherence tomography and maximum-likelihood estimation. / Huang, Jinxin; Lee, Kye Sung; Clarkson, Eric W; Kupinski, Matthew A; Maki, Kara L.; Ross, David S.; Aquavella, James V.; Rolland, Jannick P.

In: Optics Letters, Vol. 38, No. 10, 15.05.2013, p. 1721-1723.

Research output: Contribution to journalArticle

Huang, Jinxin ; Lee, Kye Sung ; Clarkson, Eric W ; Kupinski, Matthew A ; Maki, Kara L. ; Ross, David S. ; Aquavella, James V. ; Rolland, Jannick P. / Phantom study of tear film dynamics with optical coherence tomography and maximum-likelihood estimation. In: Optics Letters. 2013 ; Vol. 38, No. 10. pp. 1721-1723.
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