Pharmacokinetic properties of intravitreal I-124-aflibercept in a rabbit model using PET/CT

John B. Christoforidis, Michelle M. Williams, Shankaran Kothandaraman, Krishan Kumar, Frank J. Epitropoulos, Michael V. Knopp

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Purpose: To determine the anatomic characteristics and pharmacokinetic properties of intravitreally-placed aflibercept in a rabbit model. Materials and methods: Four Dutch-belted rabbits underwent intravitreal injection with I-124-aflibercept. Serial imaging with PET/CT imaging was performed on days 0, 2, 5, 7, 14, 21, 28 and 35. Measured radioactivity emission in becquerels/mL was used to calculate the half-lives for aflibercept. Results: I-124 aflibercept was confined within the vitreous cavity for the duration of the study. I-124 aflibercept could be detected in the vitreous cavity until day 28 and the average retention time with standard error after correction for radioactive decay was 4.58±0.07 days. Conclusions: I-124 aflibercept was only visible in the vitreous cavity by PET/CT imaging following intravitreal injection. The retention properties were found to be comparable to those measured by other reported methods.

Original languageEnglish (US)
Pages (from-to)1171-1174
Number of pages4
JournalCurrent Eye Research
Volume37
Issue number12
DOIs
StatePublished - Dec 2012

Keywords

  • Aflibercept
  • Iodine-124
  • Pharmacokinetics
  • Positron emission tomography
  • Radiolabeling

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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