Abstract
Purpose: To determine the anatomic characteristics and pharmacokinetic properties of intravitreally-placed aflibercept in a rabbit model. Materials and methods: Four Dutch-belted rabbits underwent intravitreal injection with I-124-aflibercept. Serial imaging with PET/CT imaging was performed on days 0, 2, 5, 7, 14, 21, 28 and 35. Measured radioactivity emission in becquerels/mL was used to calculate the half-lives for aflibercept. Results: I-124 aflibercept was confined within the vitreous cavity for the duration of the study. I-124 aflibercept could be detected in the vitreous cavity until day 28 and the average retention time with standard error after correction for radioactive decay was 4.58±0.07 days. Conclusions: I-124 aflibercept was only visible in the vitreous cavity by PET/CT imaging following intravitreal injection. The retention properties were found to be comparable to those measured by other reported methods.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1171-1174 |
| Number of pages | 4 |
| Journal | Current Eye Research |
| Volume | 37 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2012 |
| Externally published | Yes |
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Keywords
- Aflibercept
- Iodine-124
- Pharmacokinetics
- Positron emission tomography
- Radiolabeling
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
Cite this
Pharmacokinetic properties of intravitreal I-124-aflibercept in a rabbit model using PET/CT. / Christoforidis, John B; Williams, Michelle M.; Kothandaraman, Shankaran; Kumar, Krishan; Epitropoulos, Frank J.; Knopp, Michael V.
In: Current Eye Research, Vol. 37, No. 12, 12.2012, p. 1171-1174.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetic properties of intravitreal I-124-aflibercept in a rabbit model using PET/CT
AU - Christoforidis, John B
AU - Williams, Michelle M.
AU - Kothandaraman, Shankaran
AU - Kumar, Krishan
AU - Epitropoulos, Frank J.
AU - Knopp, Michael V.
PY - 2012/12
Y1 - 2012/12
N2 - Purpose: To determine the anatomic characteristics and pharmacokinetic properties of intravitreally-placed aflibercept in a rabbit model. Materials and methods: Four Dutch-belted rabbits underwent intravitreal injection with I-124-aflibercept. Serial imaging with PET/CT imaging was performed on days 0, 2, 5, 7, 14, 21, 28 and 35. Measured radioactivity emission in becquerels/mL was used to calculate the half-lives for aflibercept. Results: I-124 aflibercept was confined within the vitreous cavity for the duration of the study. I-124 aflibercept could be detected in the vitreous cavity until day 28 and the average retention time with standard error after correction for radioactive decay was 4.58±0.07 days. Conclusions: I-124 aflibercept was only visible in the vitreous cavity by PET/CT imaging following intravitreal injection. The retention properties were found to be comparable to those measured by other reported methods.
AB - Purpose: To determine the anatomic characteristics and pharmacokinetic properties of intravitreally-placed aflibercept in a rabbit model. Materials and methods: Four Dutch-belted rabbits underwent intravitreal injection with I-124-aflibercept. Serial imaging with PET/CT imaging was performed on days 0, 2, 5, 7, 14, 21, 28 and 35. Measured radioactivity emission in becquerels/mL was used to calculate the half-lives for aflibercept. Results: I-124 aflibercept was confined within the vitreous cavity for the duration of the study. I-124 aflibercept could be detected in the vitreous cavity until day 28 and the average retention time with standard error after correction for radioactive decay was 4.58±0.07 days. Conclusions: I-124 aflibercept was only visible in the vitreous cavity by PET/CT imaging following intravitreal injection. The retention properties were found to be comparable to those measured by other reported methods.
KW - Aflibercept
KW - Iodine-124
KW - Pharmacokinetics
KW - Positron emission tomography
KW - Radiolabeling
UR - http://www.scopus.com/inward/record.url?scp=84870256403&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870256403&partnerID=8YFLogxK
U2 - 10.3109/02713683.2012.727521
DO - 10.3109/02713683.2012.727521
M3 - Article
C2 - 22991959
AN - SCOPUS:84870256403
VL - 37
SP - 1171
EP - 1174
JO - Current Eye Research
JF - Current Eye Research
SN - 0271-3683
IS - 12
ER -