Pharmacokinetics and metabolism of retinol administered at a chemopreventive level to normal subjects.

David S Alberts, L. McDonald, L. Edwards, Y. M. Peng, M. J. Xu, D. J. Slymen, D. L. Earnest, C. Ritenbaugh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Thirteen subjects between the ages of 50 years and 70 years were administered a daily 25,000 IU dose of retinol for 9 months. Two subjects experienced mild skin dryness, headaches, and/or alopecia. There were no significant changes in serum chemistries. High performance liquid chromatography assays for plasma retinol revealed no evidence of drug accumulation; however, there was a significant increase in the plasma concentration-versus-time curve for retinyl palmitate concentrations between the first and subsequent sampling days (P = 0.009). The mean skin retinol and retinyl palmitate concentrations in 7 retinol-treated subjects (131.7 and 15.9 ng/g, respectively) were not significantly different from those observed in 13 age-matched controls (118.9 and 25.5 ng/gm, respectively).

Original languageEnglish (US)
Pages (from-to)55-64
Number of pages10
JournalCancer Detection and Prevention
Volume13
Issue number1
StatePublished - 1988

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Vitamin A
Pharmacokinetics
Skin
Alopecia
Headache
High Pressure Liquid Chromatography
Serum
Pharmaceutical Preparations
retinol palmitate

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Alberts, D. S., McDonald, L., Edwards, L., Peng, Y. M., Xu, M. J., Slymen, D. J., ... Ritenbaugh, C. (1988). Pharmacokinetics and metabolism of retinol administered at a chemopreventive level to normal subjects. Cancer Detection and Prevention, 13(1), 55-64.

Pharmacokinetics and metabolism of retinol administered at a chemopreventive level to normal subjects. / Alberts, David S; McDonald, L.; Edwards, L.; Peng, Y. M.; Xu, M. J.; Slymen, D. J.; Earnest, D. L.; Ritenbaugh, C.

In: Cancer Detection and Prevention, Vol. 13, No. 1, 1988, p. 55-64.

Research output: Contribution to journalArticle

Alberts, DS, McDonald, L, Edwards, L, Peng, YM, Xu, MJ, Slymen, DJ, Earnest, DL & Ritenbaugh, C 1988, 'Pharmacokinetics and metabolism of retinol administered at a chemopreventive level to normal subjects.', Cancer Detection and Prevention, vol. 13, no. 1, pp. 55-64.
Alberts, David S ; McDonald, L. ; Edwards, L. ; Peng, Y. M. ; Xu, M. J. ; Slymen, D. J. ; Earnest, D. L. ; Ritenbaugh, C. / Pharmacokinetics and metabolism of retinol administered at a chemopreventive level to normal subjects. In: Cancer Detection and Prevention. 1988 ; Vol. 13, No. 1. pp. 55-64.
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