Abstract
Thirteen subjects between the ages of 50 years and 70 years were administered a daily 25,000 IU dose of retinol for 9 months. Two subjects experienced mild skin dryness, headaches, and/or alopecia. There were no significant changes in serum chemistries. High performance liquid chromatography assays for plasma retinol revealed no evidence of drug accumulation; however, there was a significant increase in the plasma concentration-versus-time curve for retinyl palmitate concentrations between the first and subsequent sampling days (P = 0.009). The mean skin retinol and retinyl palmitate concentrations in 7 retinol-treated subjects (131.7 and 15.9 ng/g, respectively) were not significantly different from those observed in 13 age-matched controls (118.9 and 25.5 ng/gm, respectively).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 55-64 |
| Number of pages | 10 |
| Journal | Cancer Detection and Prevention |
| Volume | 13 |
| Issue number | 1 |
| State | Published - 1988 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Pharmacokinetics and metabolism of retinol administered at a chemopreventive level to normal subjects. / Alberts, David S; McDonald, L.; Edwards, L.; Peng, Y. M.; Xu, M. J.; Slymen, D. J.; Earnest, D. L.; Ritenbaugh, C.
In: Cancer Detection and Prevention, Vol. 13, No. 1, 1988, p. 55-64.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetics and metabolism of retinol administered at a chemopreventive level to normal subjects.
AU - Alberts, David S
AU - McDonald, L.
AU - Edwards, L.
AU - Peng, Y. M.
AU - Xu, M. J.
AU - Slymen, D. J.
AU - Earnest, D. L.
AU - Ritenbaugh, C.
PY - 1988
Y1 - 1988
N2 - Thirteen subjects between the ages of 50 years and 70 years were administered a daily 25,000 IU dose of retinol for 9 months. Two subjects experienced mild skin dryness, headaches, and/or alopecia. There were no significant changes in serum chemistries. High performance liquid chromatography assays for plasma retinol revealed no evidence of drug accumulation; however, there was a significant increase in the plasma concentration-versus-time curve for retinyl palmitate concentrations between the first and subsequent sampling days (P = 0.009). The mean skin retinol and retinyl palmitate concentrations in 7 retinol-treated subjects (131.7 and 15.9 ng/g, respectively) were not significantly different from those observed in 13 age-matched controls (118.9 and 25.5 ng/gm, respectively).
AB - Thirteen subjects between the ages of 50 years and 70 years were administered a daily 25,000 IU dose of retinol for 9 months. Two subjects experienced mild skin dryness, headaches, and/or alopecia. There were no significant changes in serum chemistries. High performance liquid chromatography assays for plasma retinol revealed no evidence of drug accumulation; however, there was a significant increase in the plasma concentration-versus-time curve for retinyl palmitate concentrations between the first and subsequent sampling days (P = 0.009). The mean skin retinol and retinyl palmitate concentrations in 7 retinol-treated subjects (131.7 and 15.9 ng/g, respectively) were not significantly different from those observed in 13 age-matched controls (118.9 and 25.5 ng/gm, respectively).
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UR - http://www.scopus.com/inward/citedby.url?scp=0024218954&partnerID=8YFLogxK
M3 - Article
C2 - 3224346
AN - SCOPUS:0024218954
VL - 13
SP - 55
EP - 64
JO - Cancer Epidemiology
JF - Cancer Epidemiology
SN - 1877-7821
IS - 1
ER -