Pharmacokinetics and metabolism of retinol administered at a chemopreventive level to normal subjects.

D. S. Alberts; L. McDonald; L. Edwards; Y. M. Peng; M. J. Xu; D. J. Slymen; D. L. Earnest; C. Ritenbaugh

Pharmacokinetics and metabolism of retinol administered at a chemopreventive level to normal subjects.

D. S. Alberts, L. McDonald, L. Edwards, Y. M. Peng, M. J. Xu, D. J. Slymen, D. L. Earnest, C. Ritenbaugh

Cancer Center

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6 Scopus citations

Abstract

Thirteen subjects between the ages of 50 years and 70 years were administered a daily 25,000 IU dose of retinol for 9 months. Two subjects experienced mild skin dryness, headaches, and/or alopecia. There were no significant changes in serum chemistries. High performance liquid chromatography assays for plasma retinol revealed no evidence of drug accumulation; however, there was a significant increase in the plasma concentration-versus-time curve for retinyl palmitate concentrations between the first and subsequent sampling days (P = 0.009). The mean skin retinol and retinyl palmitate concentrations in 7 retinol-treated subjects (131.7 and 15.9 ng/g, respectively) were not significantly different from those observed in 13 age-matched controls (118.9 and 25.5 ng/gm, respectively).

Original language	English (US)
Pages (from-to)	55-64
Number of pages	10
Journal	Cancer detection and prevention
Volume	13
Issue number	1
State	Published - 1988

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Pharmacokinetics and metabolism of retinol administered at a chemopreventive level to normal subjects.",

abstract = "Thirteen subjects between the ages of 50 years and 70 years were administered a daily 25,000 IU dose of retinol for 9 months. Two subjects experienced mild skin dryness, headaches, and/or alopecia. There were no significant changes in serum chemistries. High performance liquid chromatography assays for plasma retinol revealed no evidence of drug accumulation; however, there was a significant increase in the plasma concentration-versus-time curve for retinyl palmitate concentrations between the first and subsequent sampling days (P = 0.009). The mean skin retinol and retinyl palmitate concentrations in 7 retinol-treated subjects (131.7 and 15.9 ng/g, respectively) were not significantly different from those observed in 13 age-matched controls (118.9 and 25.5 ng/gm, respectively).",

author = "Alberts, {D. S.} and L. McDonald and L. Edwards and Peng, {Y. M.} and Xu, {M. J.} and Slymen, {D. J.} and Earnest, {D. L.} and C. Ritenbaugh",

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T1 - Pharmacokinetics and metabolism of retinol administered at a chemopreventive level to normal subjects.

AU - Alberts, D. S.

AU - McDonald, L.

AU - Edwards, L.

AU - Peng, Y. M.

AU - Xu, M. J.

AU - Slymen, D. J.

AU - Earnest, D. L.

AU - Ritenbaugh, C.

N1 - Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 1988

Y1 - 1988

N2 - Thirteen subjects between the ages of 50 years and 70 years were administered a daily 25,000 IU dose of retinol for 9 months. Two subjects experienced mild skin dryness, headaches, and/or alopecia. There were no significant changes in serum chemistries. High performance liquid chromatography assays for plasma retinol revealed no evidence of drug accumulation; however, there was a significant increase in the plasma concentration-versus-time curve for retinyl palmitate concentrations between the first and subsequent sampling days (P = 0.009). The mean skin retinol and retinyl palmitate concentrations in 7 retinol-treated subjects (131.7 and 15.9 ng/g, respectively) were not significantly different from those observed in 13 age-matched controls (118.9 and 25.5 ng/gm, respectively).

AB - Thirteen subjects between the ages of 50 years and 70 years were administered a daily 25,000 IU dose of retinol for 9 months. Two subjects experienced mild skin dryness, headaches, and/or alopecia. There were no significant changes in serum chemistries. High performance liquid chromatography assays for plasma retinol revealed no evidence of drug accumulation; however, there was a significant increase in the plasma concentration-versus-time curve for retinyl palmitate concentrations between the first and subsequent sampling days (P = 0.009). The mean skin retinol and retinyl palmitate concentrations in 7 retinol-treated subjects (131.7 and 15.9 ng/g, respectively) were not significantly different from those observed in 13 age-matched controls (118.9 and 25.5 ng/gm, respectively).

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Pharmacokinetics and metabolism of retinol administered at a chemopreventive level to normal subjects.

Abstract

ASJC Scopus subject areas

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