Pharmacokinetics and metabolism of retinol administered at a chemopreventive level to normal subjects.

D. S. Alberts, L. McDonald, L. Edwards, Y. M. Peng, M. J. Xu, D. J. Slymen, D. L. Earnest, C. Ritenbaugh

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Abstract

Thirteen subjects between the ages of 50 years and 70 years were administered a daily 25,000 IU dose of retinol for 9 months. Two subjects experienced mild skin dryness, headaches, and/or alopecia. There were no significant changes in serum chemistries. High performance liquid chromatography assays for plasma retinol revealed no evidence of drug accumulation; however, there was a significant increase in the plasma concentration-versus-time curve for retinyl palmitate concentrations between the first and subsequent sampling days (P = 0.009). The mean skin retinol and retinyl palmitate concentrations in 7 retinol-treated subjects (131.7 and 15.9 ng/g, respectively) were not significantly different from those observed in 13 age-matched controls (118.9 and 25.5 ng/gm, respectively).

Original languageEnglish (US)
Pages (from-to)55-64
Number of pages10
JournalCancer detection and prevention
Volume13
Issue number1
StatePublished - 1988

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Alberts, D. S., McDonald, L., Edwards, L., Peng, Y. M., Xu, M. J., Slymen, D. J., Earnest, D. L., & Ritenbaugh, C. (1988). Pharmacokinetics and metabolism of retinol administered at a chemopreventive level to normal subjects. Cancer detection and prevention, 13(1), 55-64.