Pharmacokinetics in the elderly

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Animals undergo substantial changes in many physiologic and biochemical functions as a natural consequence of aging. In the absence of disease or other pathologic conditions, these changes occur in a gradual manner with time (generally expressed as a fractional or percentage change in that function per year or decade). Furthermore, for any given function and at any given chronologic age, there is large variation in that function among individuals. Given the increase in life expectancy, the substantial increase in the number of elderly (and aged elderly) in the population, and the escalating costs of health care, there is great interest in learning more about the risks associated with aging as a result of toxic exposure. Are the elderly at greater risk than younger adults to the toxic effects of drugs and environmental exposure? Is the elderly population an inherently more sensitive one?

Original languageEnglish (US)
Pages (from-to)119-124
Number of pages6
JournalEnvironmental health perspectives
Volume102
Issue numberSUPPL. 11
DOIs
StatePublished - Jan 1 1994

Keywords

  • Absorption
  • Aging
  • Distribution
  • Excretion
  • Metabolism
  • Pharmacokinetics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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